肺癌患者外周血液端粒酶活性检测结果与预后的关系  

Relation between the Detecting Results of Telomerase Activity in the Peripheral Blood from the Patients with Lung Cancer and the Prognosis of the Patients

作　　者：侯继申[1] 杜新生[2] 薛承岩[3] 邸志强[2] 杨亚平[3] 卢冬梅[3] 

机构地区：[1]承德医学院附属医院胸外科,河北承德067000 [2]承德医学院附属医院肿瘤科,河北承德067000 [3]承德医学院附属医院检验科,河北承德067000

出　　处：《现代检验医学杂志》2009年第2期113-114,共2页Journal of Modern Laboratory Medicine

基　　金：2007年河北省科学技术支撑计划项目（编号：07276101D-2）,2008年承德市科学研究与发展计划项目（编号：200821127）.

摘　　要：目的了解肺癌患者外周血液端粒酶活性（TA）检测结果与预后的关系。方法应用端粒重复序列扩增-微孔板杂交-酶联免疫分析检测肺癌患者外周血液TA，比较TA阳性与阴性患者3年生存情况。结果TA阴性组52例患者1～3年生存例数分别为31例、10例和2例，TA阳性组45例患者1～3年生存例数分别为12例、1例和0例，TA阴性组的1～2年生存例数显著多于阳性组（P〈0．05）。结论检测外周血液TA有助于肺癌预后的评估，TA阴性者的生存情况明显好于阳性者。Objective To explore the relation between the detecting results of telomerase activity （TA） in the peripheral blood from the patients with lung cancer and the prognosis of the patients. Methods TA was detected by telomeroc repeat amplification protocol-hybridism-enzyme-linked immunosorbent assay in peripheral blood from the cases of lung cancer. The llfe cycle of 3 years were compared between the positive index of TA and the negative in the blood of the patients. Results The survival cases of 1 into 3 years were 31 cases, 10 cases and 2 cases in the negative TA group of 52 patients with Iung cancer;the survival cases were 12 cases, 1 case and 0 case in the positive group of 45 patients with lung cancer. The survival cases in the negative TA group especially 1 into 2 years were much more than the patients in the positive group （P〈0. 05）. Conclusion The detection of TA in the peripheral blood is useful index in the objective estimate of the prognosis of the patients with lung cancer. The negative TA cases have clear superiority than the positive cases in the survival.

关 键 词：肺癌 外周血液 端粒酶活性 预后 

分 类 号：R730.43[医药卫生—肿瘤]