尿胰蛋白酶原-2对诊断急性胰腺炎的临床应用  

Clinical Application of Urinary Trypsinogen-2 in Diagnosing Acute Pancreatitis

作　　者：周铁成[1] 杨小云[1] 秦庆[1] 张莹[1] 童开[1] 袁亚娟[1] 郝晓柯[1] 

机构地区：[1]第四军医大学西京医院全军临床检验医学中心,西安710032

出　　处：《现代检验医学杂志》2009年第2期119-121,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨快速试纸法检测尿胰蛋白酶原-2在急性胰腺炎（acute pancreatitis，AP）诊断中的临床意义。方法对150例急腹症患者（其中重型100例，轻型50例）的血清和尿液标本分别测定尿胰蛋白酶原-2和血、尿淀粉酶（AMY）活性，并将结果进行比较。结果尿胰蛋白酶原-2检测的敏感度、特异度分别为90．1％和91．5％；血AMY为81．3％和81．4％；尿AMY为74．7％和72．8％。尿胰蛋白酶原-2对AP诊断的敏感度和特异度显著高于血、尿AMY检测。结论快速试纸法检测尿胰蛋白酶原-2是急腹症患者中筛选急性胰腺炎快速而简便的方法，具有较高的特异度和敏感度。Objective To study the clinical significance of urinary trypsinogen-2 in diagnosing acute pancreatitis with rapid paper method. Methods Examined urinary trypsinogen-2, blood and urine amylase activity separately in 150 cases of acute abdomen （100 with severe disease, 50 with mild disease） with their serum and urine samples,and then compared the results. Results The sensitivity and particularity of urinary trypsinogen-2 test in diagnosing acute pancreatitis respectively was 90.1% and 91.5% ,blood amylase was 81.3% and 81.4% ,and urine amylase was 74.7% and 72.8%. The sensitivity and particularity of urinary trypsinogen-2 was much higher than blood or urine amylase. Conclusion Rapid paper method measured urinary trypsinogen-2 for diagnosing acute pancreatitis is a simple and fast method ,which is also higher in particularity and sensitivity.

关 键 词：尿胰蛋白酶原-2 急性胰腺炎 淀粉酶 急腹症 

分 类 号：R576[医药卫生—消化系统] R446.112[医药卫生—内科学]