溶剂化对修饰超氧化物歧化酶稳定性的影响  

Solvation Interaction and Stability of Modified Superoxide Dismutase

作　　者：李维忠[1] 缪方明[1] 

机构地区：[1]天津师范大学晶体化学研究所

出　　处：《物理化学学报》1998年第4期289-292,共4页Acta Physico-Chimica Sinica

基　　金：天津市高等教育局重点学科资助

摘　　要：The stability of Copper, Zinc superoxide dismutase increases remarkably when thelysines on the surface of the enzyme are modified. The fmite difference solution to the Poisson-Boltzman equation (FDPB) method is usedf to calculate the electrostatic interaction between so-lution and enzyme. The resnlts show that the reaction field energy of SOD is reduced by about,1270kJ·mol-1 after modification.The stability of Copper, Zinc superoxide dismutase increases remarkably when thelysines on the surface of the enzyme are modified. The fmite difference solution to the Poisson-Boltzman equation (FDPB) method is usedf to calculate the electrostatic interaction between so-lution and enzyme. The resnlts show that the reaction field energy of SOD is reduced by about,1270kJ·mol-1 after modification.

关 键 词：稳定性 超氧化物歧化酶 化学修饰 溶剂化 

分 类 号：Q554.02[生物学—生物化学]