胃肠癌患者营养不良与免疫状况的关系  

Combined Determination of Nutritional and Immune Status in Patients with Gastrointertinal Cancer

作　　者：彭俊生[1] 王吉甫[1] 王颀[1] 

机构地区：[1]中山医科大学附属第一医院胃肠外科,510080

出　　处：《广东医学》1998年第2期92-94,共3页Guangdong Medical Journal

摘　　要：目的：探讨胃肠癌患者的营养和免疫状况以及营养不良与免疫状况的关系。方法：检测了多项营养和免疫指标，分析了92例胃肠癌患者的营养和细胞免疫状况。结果：①胃肠癌患者的营养不良发生率为25．0％。②胃肠癌患者外用血NK细胞活性、淋巴细胞转化率、CD3及CD4细胞都较对照组低（P＜0．01）。③营养不良的癌症患者，NK细胞活性、淋巴细胞总数（TLC）和CD4／CD8比值较营养良好者下降（P＜0．05）。结论：胃肠癌患者常存在着营养不良和细胞免疫功能低下，营养不良可加重患者免疫功能的损害。Objective:To study the relationship between the malnutrition and the immune status in patients with gastrointestinal cancer. Methods: Nutritional and immunological parameters were determined in 92 patients with gastrointestinal cancer. Nutritional and immune status and the effect of malnutrition on immune function were analysed. Results: ①25.0% (23) of the 92gastrointestinal canoer patients suffered from malnutrition. ②NK cell activity, lymphocyte transformation rate(LTR), CD3 and CD4 cells percentages of the cancer group were significantly lower than that of the non - cancer control group(P < 0.10). ③NK cell activity, total lymphocyte count(TLC), and CD4/CD8 ratios of the malnutrition cancer group were significantly lower than that of the well-nourished group(P < 0.05). Conclusions: Malnutrition and immunosuppression often coexist in patients with gastrointestinal caner. Malnutrition might aggravate immune dysfunction. NK cell activity, TLC and CD4/CD8 ratios might be the immunological parameters that erlate to mutritional status.

关 键 词：胃肠道 肿瘤 营养不良 免疫 

分 类 号：R735.06[医药卫生—肿瘤] R591.03[医药卫生—临床医学]