胆囊癌 p53 蛋白表达及临床意义  

p53 EXPRESSION OF GALLBLADDER CARCINOMA AND ITS CLINICAL SIGNIFICANCE

作　　者：国长军[1] 郑泽霖[2] 

机构地区：[1]烟台市毓璜顶医院肿瘤科 [2]白求恩医科大学第三临床学院普外科

出　　处：《山东医科大学学报》1998年第1期71-73,共3页Acta Academiae Medicinae Shandong

摘　　要：应用免疫组化方法观察４３例胆囊癌组织ｐ５３蛋白的表达并探讨其临床意义。结果发现：胆囊癌阳性表达率为５１．２％，胆囊腺瘤及慢性胆囊炎均为阴性；未分化癌ｐ５３蛋白阳性率明显高于高、中分化腺癌和低分化腺癌（Ｐ＜０．０５）；ｐ５３蛋白阳性表达与淋巴结转移有关，而与病人的年龄、性别、伴有结石无明显相关性。结果表明：（１）ｐ５３蛋白在胆囊癌组织中有较高的表达率；（２）ｐ５３蛋白阳性的病例恶性程度高、预后较差，ｐ５３蛋白可能是反映胆囊癌生物学行为和预后的重要标记，在胆囊癌发生发展中可能有重要意义。The expression of p53 was investigated in 43 cases of gallbladder carcinoma with immunohistochemical method and its clinical significance was discussed.No positive expression of p53 was found in gallbladder adenomas and chronic cholecystitis,while the positive rate of p53 in gallbladder carcinomas was 51.2%.The incidence of p53 positivity in undifferentiated carcinomas was significantly higher than that in poorly or moderately and well differentiated ones(P<0.05).p53 positivity was related to lymphatic metastasis,but there were no correlations between p53 positivity and patient's age,sex and the presence of gallbladder stones.The results suggest that the cases with p53 positivity have a poor prognosis and p53 may play some roles in the pathogenesis and development of gallbladder carcinoma.

关 键 词：胆囊肿瘤 P53蛋白 免疫组化 

分 类 号：R735.802[医药卫生—肿瘤]