AS—OCT与A超测量中央角膜厚度与前房深度的比较  

Comparison of central corneal thickness and anterior chamber depth measurements using the Anterior Segment Optical Coherence Tomography and A-scan ultrasonography

作　　者：曾阳发[1] 李彬彬[1] 黄国富[1] 李月桃[1] 何明光[1] 

机构地区：[1]眼科学国家重点实验室 中山大学中山眼科中心,广州510060

出　　处：《中国实用眼科杂志》2009年第4期380-383,共4页Chinese Journal of Practical Ophthalmology

摘　　要：目的探讨眼前段光学相干断层扫描技术（anterior segment optical coherence tomography，AS—OCT）和A型超声波生物测量技术（A超）测量，中央角膜厚度（central corneal thickness，CCT）和前房深度（antefior chamber depth，ACD）的异同。方法分别采用AS—OCT和A超测量33名（54只眼）正常人的CCT和ACD，分别采用配对t检验、Pearson相关和Bland—Ahman方法，分析两种仪器的测量值的差异、相关性和一致性。结果A超与AS—OCT的CCT值分别为（524．41±23．24）um、（513．37±22．71）um，之间的差异有统计学意义（1=-15．906，P=0．000），差值均数为（11．04±5．10）um。两种仪器的CCT值正相关（r=0．976，P=0．000）。95％LoA（95％ Limts of Agreement）为（-21．03，-1.04）um，95％LoA的区间范围为19．99um，为A超CCT平均值的3．81％。A超与AS—OCT的ACD值分别为（2．89±0．29）mm、（3．18±0．26）mm，之间的差异有统计学意义（t=-12．052，P=0．000），差值的均数为（-0．29±0．17）mm。两种仪器的ACD值相关（r=0．803，P=0．000）。95％LoA为（-0．63，-0．06）mm，95％LoA的区间范围为0．57mm，为A超ACD平均值的19．72％。结论AS-OCT的CCT值和ACD值与A超的测量值相关。与A超相比，AS—OCT的CCT测量值更小，而ACD值更大。两种仪器测量CCT的一致性比ACD高。Objective To assess central corneal thickness （CCT）and anterior chamber depth（ACD） measurements with anterior segment optical coherence tomography （AS-OCT）comparing with A-scan ultrasonography （A-scan US ）.Methods 54 eyes of 33 normal subjects were enrolled in the study.CCT and ACD were measured using AS-OCT and A-scan US.The measurements of two instruments were analyzed using paired t test,Pearson correlation and Bland-Altman plot,respectively.Results The CCT of AS-OCT and A-scan US were 524.41±23.24 microm and 513.37±22.7 microm,respectively.The CCT values measured by A-scan US were significantly greater than AS-OCT,paired difference was 11.04± 5.10 microm （t =15.906, P =0.000）.There were a significantly correlation between CCTs value of two instruments （r =0.976, P =0.000）. The 95% LoA （95% Limts of Agreement ）was -21.03 microm to -1.04 microm.The width of 95% LoA was 28 microm, 3.81% of the average pachymetry reading.The ACD of AS-OCT and A-scan US were 2.89± 0.29 mm and 3.18 ± 0.26 mm,respectively.The ACD values measured by AS-OCT were significantly greater than A-scan US, paired difference was -0.29±0.17 mm（ t =- 12.052, P = 0.000 ）.There were a significantly correlation between CCTs value of two instruments（r=0.803, P=0.000）.The 95% LoA was -0.63 mm to -0.06 mm.The width of 95% LoA was 0.57 mm, 19.72% of the average A-scan reading.Conclusion CCT and ACD measured by AS-OCT were highly correlated with that from ultrasound pachymetry.In comparison with measurements of A-scan, CCT value of AS-OCT was lower, and the ACD was deeper.However, ACD readings by AS-OCT and A-scan were consistently less than that of CCT.

关 键 词：中央角膜厚度 前房深度 一致性 光学相干断层扫描 

分 类 号：R778.11[医药卫生—眼科] R322.91[医药卫生—临床医学]