双氯芬酸钠-β-环糊精包合物的研制  

The preparation of inclusion compound of diclofenac sodiumβcyclodextrin

作　　者：谷福根[1] 柳翠敬[1] 

机构地区：[1]北京医科大学药剂教研室

出　　处：《中国药学杂志》1998年第3期153-155,共3页Chinese Pharmaceutical Journal

摘　　要：目的：制备双氯芬酸钠β环糊精包合物考察其有关性质。方法：采用共沉淀法制备双氯芬酸钠β环糊精包合物。结果：经ＵＶ，ＩＲ，ＤＳＣ及相溶解度图法鉴定，表明双氯芬酸钠与β环糊精确已形成包合物，含量测定证明包合物主、客分子比为１∶１。结论：双氯芬酸钠β环糊精包合物可明显提高双氯芬酸钠的溶解度、溶出速度，并减小其对胃粘膜的刺激性。OBJECTIVE: To prepare the inclusion compound of diclofenac sodium (DFS)βcyclodextrin (βCD) and investigate its properties. METHOD: The inclusion compound of DFSβCD was prepared by the coprecipitation method. RESULTS: The inclusion compound of DFSβCD was confirmed by UV absorption spectrum, IR absorption spectroscopy, differential scanning calorimetry (DSC) and phase solubility diagram. Meanwhile, the content analysis of the inclusion compound showed that the molecular ratio of DFS to βCD was 1∶1. CONCLUSION: The soluability and dissolution rate of DFS were increased and its irritation to stomach was reduced when the drug was included by βCD.

关 键 词：双氯芬酸钠 Β-环糊精 包合物 

分 类 号：R971.1[医药卫生—药品] R944.9[医药卫生—药学]