海南粗榧新碱衍生物HH07A在大鼠体内的代谢转化研究  

STUDIES ON URINARY METABOLITES OF HH07A, A DERIVATIVE OF HAINANENSINE, IN RATS

作　　者：张文江[1] 周同惠[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所

出　　处：《药学学报》1998年第3期212-216,共5页Acta Pharmaceutica Sinica

摘　　要：用ＧＣＭＳ联用技术对海南粗榧新碱衍生物ＨＨ０７Ａ在大鼠体内代谢转化进行了研究。尿样经ＸＡＤ２固相提取、酶水解、浓缩并硅烷化，用ＧＣＭＳ联用仪分离鉴定尿中ＨＨ０７Ａ及其４个代谢物，推断４个代谢物结构及其体内代谢途经。The metabolism of HH07A in the rat has been investigated by GCMS. After oral administration of HH07A, the rat urine was passed through a macroporous XAD2 resin column and eluted with methanol. The methanol extract was hydrolyzed with glucuronidase, extracted with dichloromethane and concentrated for TMS derivatization with GCMS. The mass spectra of HH07A and its four metabolites as well as their derivatives were presented. The structures of the metabolites were proposed and the in vivo metabolic pathway of HH07A was given in Figure 6.

关 键 词：海南粗榧心碱 生物碱 体内代谢 气质联用 

分 类 号：R979.1[医药卫生—药品] R931.71[医药卫生—药学]