散发性阿尔茨海默病患者脑内sorLA水平与淀粉样斑块数量的关系  

The Correlation of SorLA Levels and Plaques and Beta-amyloid(Aβ) Loads in AD Brains

作　　者：程忻[1] 董强[1] 申勇[1,2] 

机构地区：[1]复旦大学附属华山医院神经内科,上海200040 [2]Haldeman Laboratory of Molecular and Cellular Neurobiology,Sun Health Research Institute,suncityaz85351

出　　处：《神经损伤与功能重建》2009年第2期94-97,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:研究散发性阿尔茨海默病(AD)患者脑内sorLA蛋白表达水平,并探讨其与脑内淀粉样斑块数量的关系。方法:随机选择15例尸检明确诊断的散发性AD患者(AD组)和15例非AD患者(对照组),采用Western-blot测定2组颞叶皮质组织中sorLA蛋白表达水平,并分析AD组脑内sorLA水平与淀粉样斑块数量的关系。结果:2组性别、年龄、死后尸检时间等匹配。AD组颞叶皮质内sorLA蛋白表达水平较对照组下降达63%(P<0.05),线性回归分析显示AD组脑内sorLA水平与淀粉样斑块数量明显呈反比。结论:散发性AD患者脑内sorLA蛋白表达显著下降,且其表达量与淀粉样β蛋白(Aβ)的沉积量直接相关,提示sorLA可能涉及散发性AD的发病机制。Objective： To determine the levels of sorLA in the brains of Alzheimer＇s Disease fAD） patients, and to observe the correlation of sorLA levels and plaques and beta-amyloid （Aβ） loads in AD brains. Methods： We have randomly selected 15 autopsy-confirmed sporadic AD and 15 control individuals, and quantitatively analyzed protein levels of sorLA in the temporal cortex with Western-blotting analysis and its association with plaque numbers in AD brains has been explored. Results： Patients having sporadic AD expressed significantly less sorLA protein in the temporal cortex when compared with controls. SorLA was decreased in the sporadic AD cases by 63% （P（0.05）. By using linear regression analysis, we observed significant inverse correlations between levels of sorLA and plaque numbers in AD brains. Conclusion： The results of the current study suggest that sorLA loss might be an important factor in AD pathogenesis.

关 键 词：阿尔茨海默病 sorLA/LR11 淀粉样Β蛋白 淀粉样斑块 

分 类 号：R741[医药卫生—神经病学与精神病学] R749.16[医药卫生—临床医学]