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作 者:李艳红[1,2] 应永意[1,2] 赵亚萍 丁思奇 候健[1,2]
机构地区:[1]第二军医大学长征医院血液科 [2]江苏淮阴市解放军82医院
出 处:《免疫学杂志》1998年第2期111-112,共2页Immunological Journal
摘 要:为了解可溶性白细胞介素6受体(sIL-6R)在恶性淋巴瘤(ML)中的作用及意义,运用ELISA法检测30例ML患者及20例正常对照者血清sIL-6R浓度。结果表明:Ⅳ期ML患者明显高于正常对照及Ⅰ、Ⅱ、Ⅲ期患者;未缓解组(23例)明显高于缓解组(7例);P均<0.01;Ⅰ、Ⅱ、Ⅲ期及缓解组与正常对照组相差不显著(P>0.05)。提示血清sIL-6R浓度与ML患者病情有关,可作为临床判断病情的良好指标。In order to investigate the function and significance of soluble interleukin 6 receptor (sIL6R) in malignant lymphoma(ML), we determined the serum sIL6R concentrations of 30 ML patients and 20 normal controls using ELISA method. Our results showed that the serum concentrations of sIL6R at stage Ⅳ in ML were significantly higher than those of normal controls and ML at stage Ⅰ,Ⅱ,Ⅲ(P<0.01), and those of unremission group (23 cases) also significantly higher than those of remissoin group (P<0.01), there were no significant differences among ML at stage Ⅰ,Ⅱ,Ⅲ, remission group and normal controls. That means the serum concentration of IL6R in ML has relation with disease progressing. It is a useful maker in reflecting disease severity in ML. Its value in clinical practice and its clinical significance in ML need further investigation.
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