恶性淋巴瘤血清sIL-6R检测的临床意义  被引量:2

CLINICAL SIGNIFICANCE OF DETERMINING SERUM SOLUBLE INTERLEUKIN6 RECEPTOR IN MALIGNANT LYMPHOMA

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作  者:李艳红[1,2] 应永意[1,2] 赵亚萍 丁思奇 候健[1,2] 

机构地区:[1]第二军医大学长征医院血液科 [2]江苏淮阴市解放军82医院

出  处:《免疫学杂志》1998年第2期111-112,共2页Immunological Journal

摘  要:为了解可溶性白细胞介素6受体(sIL-6R)在恶性淋巴瘤(ML)中的作用及意义,运用ELISA法检测30例ML患者及20例正常对照者血清sIL-6R浓度。结果表明:Ⅳ期ML患者明显高于正常对照及Ⅰ、Ⅱ、Ⅲ期患者;未缓解组(23例)明显高于缓解组(7例);P均<0.01;Ⅰ、Ⅱ、Ⅲ期及缓解组与正常对照组相差不显著(P>0.05)。提示血清sIL-6R浓度与ML患者病情有关,可作为临床判断病情的良好指标。In order to investigate the function and significance of soluble interleukin 6 receptor (sIL6R) in malignant lymphoma(ML), we determined the serum sIL6R concentrations of 30 ML patients and 20 normal controls using ELISA method. Our results showed that the serum concentrations of sIL6R at stage Ⅳ in ML were significantly higher than those of normal controls and ML at stage Ⅰ,Ⅱ,Ⅲ(P<0.01), and those of unremission group (23 cases) also significantly higher than those of remissoin group (P<0.01), there were no significant differences among ML at stage Ⅰ,Ⅱ,Ⅲ, remission group and normal controls. That means the serum concentration of IL6R in ML has relation with disease progressing. It is a useful maker in reflecting disease severity in ML. Its value in clinical practice and its clinical significance in ML need further investigation.

关 键 词:ELISA 淋巴肉瘤 白细胞介素6 

分 类 号:R733.403[医药卫生—肿瘤]

 

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