白细胞介素-12B基因多态性与胃癌遗传易感性的关系  

Relationship Between IL-12B Gene Polymorphism and the Susceptibility of Gastric Cancer

作　　者：吴娟[1] 路滟[1] 徐耀初[1] 

机构地区：[1]南京医科大学公共主主事院流行病与卫生统计学系,江苏南京210029

出　　处：《中国肿瘤》2009年第4期322-324,共3页China Cancer

基　　金：国家自然科学基金(30671814)

摘　　要：[目的]研究白细胞介素(IL-12B)基因3′UTR(A1188C)位点多态性与江苏地区胃癌发生的关系。[方法]采用聚合酶链反应—限制性片段长度多态性(RFLP)分析法检测1045例胃癌新发病例和1100例与病例性别、年龄匹配的健康对照人群的IL-12B基因1188A/C位点多态性。[结果]IL-12B基因1188A/C位点基因多态性在正常人群和胃癌患者中的分布无显著性差异(P>0.05),但在饮酒的人群中,携带1188C等位基因可降低患胃癌的危险(OR=0.69,95%CI=0.47～0.99)。[结论]IL-12B基因1188A/C位点基因多态性可能与江苏地区饮酒人群胃癌的发生有关。[Purpose] To investigate the relationship between IL-12B gene 3＇UTR （1188A/C）polymorphism and the carcinogenesis for gastric cancer in Jiangsu province. [Method] The polymorphism of IL-12B 1188A/C was analyzed by PCR-restriction fragment length polymorphism （PCRRFLP） in 1 045 cases with gastric cancer and 1 100 cases of health coutrols matched with sex and age. [Result] IL-12B gene polymorphism （1188A/C） between gastric cancer patient and healthy person was not significantly different（P〉0.05）, but in population of alcohol comsumer with 1188C carrier the risk of susceptibility for gastric cancer was reduced （OR =0.69,95% CI =0.47 -0.99）. [Conclusion] Polymorphism of IL-12B gene 1188A/C might relate to carcinogenesis for gastric cancer in Jiangsu province.

关 键 词：白细胞介素-1213 胃肿瘤 基因多态性 流行病学 

分 类 号：R735.2[医药卫生—肿瘤]