海藻酸钙/几丁聚糖微胶囊载胰蛋白酶研究  

Research of drug-loaded calcium alginate/chitosan microcapsules

作　　者：李莉[1] 王士斌[1] 刘源岗[1] 陈爱政[1] 蓝琪[1] 

机构地区：[1]华侨大学化工学院,福建厦门361021

出　　处：《化工进展》2010年第S2期305-309,共5页Chemical Industry and Engineering Progress

基　　金：国家863计划项目(2006AA02A118);国家自然科学基金项目(30370415);福建省自然科学基金项目(C0710034;2009J01253)资助

摘　　要：采用乳化固化法制备出平均粒径为820 nm的海藻酸钙空白微胶珠,并以几丁聚糖为膜材进一步制备了海藻酸钙/几丁聚糖微胶囊。以胰蛋白酶(Trypsin)为模型药物,采用两步法制备了载胰蛋白酶/几丁聚糖-海藻酸钙微胶囊,考察了几丁聚糖分子量、几丁聚糖浓度、成膜时间、投药浓度等工艺参数对微胶囊载药性能的影响,结果表明几丁聚糖-海藻酸钙微胶囊对胰蛋白酶具有较好的负载性能。The calcium alginate microbeads with a mean size of 820nm were prepared by emulsification process at the first place,then the chitosan/calcium alginate microcapsules were produced by coating chitosan on the microbeads.Using trypsin as a model drug,trypsin-loaded chitosan/calcium alginate microcapsules were obtained through a two-step method,and the influences of different concentrations of drug,different molecular weight and concentrations of chitosan,different membrane forming time on the drug load were investigated.The results show that the chitosan/calcium alginate microcapsules could be potential carrier for loading trypsin.

关 键 词：乳化法 几丁聚糖 微胶囊 载药性能 

分 类 号：R944[医药卫生—药剂学]