肿瘤标记物的联合检测在结肠癌中的应用  

The application of combined defection of serum tumor markers levels of patients with colon cancer

作　　者：付红兵[1] 王为民[1] 蔡清萍[1] 

机构地区：[1]第二军医大学长征医院普外二科,上海200003

出　　处：《中华临床医师杂志（电子版）》2012年第17期5087-5090,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨CEA、CA19-9、CA72-4、CA125和CA242联合检测在结肠癌诊断和疗效评价中的临床价值。方法检测72例结肠癌患者术前及术后1个月和50例健康体检者外周血清中肿瘤标记物CEA、CA19-9、CA72-4、CA125和CA242的水平,比较结肠癌患者血清中肿瘤标记物的变化,并计算肿瘤标记物诊断结肠癌的敏感性、特异性及准确性。结果结肠癌患者血清中各肿瘤标记物测定值明显高于对照组[CEA:(29.10±9.80)ng/ml vs.(2.35±0.73)ng/ml;CA19-9:(52.37±13.21)U/ml vs.(10.53±3.07)U/ml;CA72-4:(17.63±5.09)U/ml vs.(4.79±1.93)U/ml;CA125:(62.48±15.36)U/ml vs.(5.41±1.27)U/ml;CA242:(89.34±21.06)U/ml vs.(7.25±2.79)U/ml],阳性率亦高于对照组。术前测定的含量明显高于术后[CEA:(29.10±9.80)ng/ml vs.(18.42±8.56)ng/ml;CA19-9:(52.37±13.21)U/ml vs.(33.59±7.43)U/ml;CA72-4:(17.63±5.09)U/ml vs.(11.75±4.18)U/ml;CA125:(62.48±15.36)U/ml vs.(38.74±11.36)U/ml;CA242:(89.34±21.06)U/ml vs.(51.64±12.76)U/ml],差异有统计学意义(P均<0.05)。标记物联合检测的敏感性和诊断准确性均比单项检测高,其中单项以CEA敏感性最高。结论 CEA、CA19-9、CA72-4、CA125和CA242联合检测对结肠癌的诊断、疗效观察及复发预测是较理想的检测手段,具有重要的临床意义。Objective To explore the clinical value of combined detection of serum CEA,CA19-9,CA72-4,CA125 and CA242 levels for diagnosis and evaluation of colon cancer.Methods Detection of serum tumor markers CEA,CA19-9,CA72-4,CA125 and CA242 were carried out in 72 patients with colon cancer and 50 healthy volunteer.The changes of preoperative and postoperative in colon cancer group were observed,and sensitivity,specificity and accuracy of tumor marker in the diagnosis of colon cancer was calculated.Results The concentrations of these tumor markers and the positive ratio in the patients with colon cancer were significantly higher than those in the control group.The concentrations of the five markers in the cases of preoperation were higher than that of postoperationand differences were statistically significant,all P<0.05.If serum CEA,CA19-9,CA72-4,CA125 and CA242 were detected simultaneously,the sensitivity and specificity of diagnosis of colon cancer could be improved,and sensitivity of CEA was the highest in one individual.Conclusions The combined detection of serum CEA,CA19-9,CA72-4,CA125 and CA242 levels has better clinical value in auxiliary diagnosis and evaluation of colon cancer and is of important clinical significance in the diagnosis,evaluation and predict recurrence of colon cancer.

关 键 词：肿瘤标记 生物学 结肠肿瘤 

分 类 号：R735.35[医药卫生—肿瘤]