原发性胆汁性肝硬化患者健康相关生存质量调查  

Health-related quality of life in Chinese patients with primary biliary cirrhosis

作　　者：高峰[1] 高茹[1] 李光[1] 郝建宇[1] 

机构地区：[1]首都医科大学附属北京朝阳医院消化内科,100020

出　　处：《中华临床医师杂志（电子版）》2012年第17期5171-5174,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的研究中国原发性胆汁性肝硬化患者健康相关生存质量及其影响因素。方法所有受试者回答SF-36 v2中文版量表,通过SF-36 v2软件计算出:生理功能、生理职能、躯体疼痛、总体健康、活力、社会功能、情感职能、精神健康共八个维度,以及躯体健康总评和精神健康总评。同时登记所有受试者的一般资料和临床资料。结果 64例原发性胆汁性肝硬化患者(女56例,男8例),38例健康对照者(女34例,男4例)参与调查。健康对照组、原发性胆汁性肝硬化患者躯体健康总评评分分别为54.3±4.0,46.8±8.1(P<0.001);精神健康总评评分分别为56.3±4.8,51.0±6.5(P<0.001)。逐步法线性回归分析显示年龄、女性性别、出现腹水、凝血酶原时间对患者健康相关生存质量呈负影响;健康感觉、白蛋白水平、白细胞值对患者健康相关生存质量呈正影响。结论原发性胆汁性肝硬化患者健康相关生存质量明显低于健康人群。年龄、女性性别、出现腹水、凝血酶原时间延长是降低患者健康相关生存质量的重要因素。好的健康感觉、高白蛋白值可以改善患者健康相关生存质量。Objective To investigate health-related quality of life(HRQOL)in Chinese patients with primary biliary cirrhosis(PBC)and its influencing factors.Methods HRQOL was measured with the Medical Outcomes Study of Short Form SF-36 v2 Chinese version.SF-36 v2 soft computed the results of physical function,physical roles,bodily pain,general health,vitality,social roles,emotional roles,mental health,physical component summary,and mental component summary.Demographic and clinical data were collected at admission.Independent sample t test was used to compare the HRQOL scores of different groups,and stepwise linear regression analysis was used to investigate the HRQOL scores′ demographic and clinical influencing factors.Results 64 Chinese patients with PBC(56 female,8 male),and 38 healthy controls(34 female,4 male)were enrolled in the study.Compared with healthy controls,patients with PBC had impaired HRQOL on multiple domains of SF-36,except the domain of BP.Stepwise linear regression analysis showed that age,female gender,present ascites,and prolonged prothrombin time had negative effect on multiple domains of SF-36.Good health perception,high level of albumin and white blood cell had positive effect on multiple domains of SF-36.Conclusions Patients with PBC had impaired HRQOL.Age,female gender,present ascites and prolonged prothrombin time are important factors reducing HRQOL.Good health perception and high level of albumin may improve HRQOL.

关 键 词：肝硬化 胆汁性 生活质量 

分 类 号：R575.2[医药卫生—消化系统]