埃兹蛋白在皮肤鳞状细胞癌、基底细胞上皮瘤、脂溢性角化病中的表达及临床意义  

Expression of ezrin in squamous cell carcinoma, basal cell carcinoma and seborrheic keratosis

作　　者：罗鑫[1] 伍斌[2] 唐发清[3] 张江林[2] 谢红付[2] 李吉[2] 

机构地区：[1]中南大学湘雅二医院病理科,长沙410011 [2]中南大学湘雅医院皮肤科 [3]中南大学湘雅医院检验科

出　　处：《中华皮肤科杂志》2009年第4期248-250,共3页Chinese Journal of Dermatology

摘　　要：目的探讨埃兹蛋白（ezrin）在脂溢性角化病、基底细胞上皮瘤、皮肤鳞状细胞癌中的表达及其与临床病理参数之间的相关性。方法采用免疫组化法（SP法）检测36例皮肤鳞状细胞癌、27例基底细胞上皮瘤和20例脂溢性角化病、10例正常人皮肤中埃兹蛋白表达水平。结果埃兹蛋白在正常人皮肤、脂溢性角化病、基底细胞上皮瘤、皮肤鳞状细胞癌中的阳性率分别为20．0％，25．0％，66．7％和91．3％，除脂溢性角化病组外，各肿瘤组与正常人对照组比较，阳性率差异均有统计学意义（H=40．061，P〈0．01）。埃兹蛋白表达水平与皮肤肿瘤良恶性、与皮肤鳞状细胞癌的病理分级及肿瘤有无淋巴结转移均呈正相关（r分别为0．87，0．80，0．89）。COX回归显示，埃兹蛋白表达水平是皮肤鳞状细胞癌预后的独立影响因素之一。结论脂溢性角化病、基底细胞上皮瘤、皮肤鳞状细胞癌组织中埃兹蛋白阳性表达水平与皮肤肿瘤的良恶性、皮肤鳞状细胞癌病理分级及有无淋巴结转移有关。Objective To investigate the expression of ezrin in seborrheic keratosis （SK）, basal cell carcinoma （BCC）, squamous cell carcinoma （SCC） and its relation to clinical pathology parameters. Methods Skin samples were collected from 36 patients with SCC, 27 patients with BCC, 20 patients with SK and 10 normal human controls. Immunohistochemistry was performed to detect the expression of ezrin in these samples. The relationship between ezrin expression and prognosis of SCC was assessed using COX regression analysis. Results The positivity rate of ezrin in SK, BCC and SCC samples was 25.0%, 66.7%, 91.3%, respectively, compared to 20.0%. in normal controls. Compared with the controls, a significant increase was observed in the expression of ezrin in patients with BCC and SCC （both P 〈 0.05 ）, but not in those with SK （P 〉 0.05 ）. Moreover, increased expression level of ezrin was correlated with a high degree of tumor malignancy, advanced pathological stage, and occurrence of lymph node metastasis of SCC （r = 0.87, 0.80, 0.89, respectively, all P 〈 0.01 ）. COX regression analysis revealed that the expression level of ezrin was an independent factor for the prognosis of SCC. Conclusion The expression level of ezrin is closely related to the malignancy of skin tumors, pathological grading and lymph node metastasis of SCC.

关 键 词：角化病 脂溢性 癌 基底细胞 癌 鳞状细胞 埃兹蛋白 

分 类 号：R739.5[医药卫生—肿瘤] R730.261[医药卫生—临床医学]