良恶性原发肝肿瘤患者血IL-18及IL-18BP含量测定及临床意义  

Clinical Significance of Serum IL-18 and IL-18BP in Patients with Benign or Malignant Primary Liver Tumor

作　　者：官成浓[1] 廖湘晖[1] 罗海清[1] 陈星明[1] 陈宝英[1] 张培文[1] 

机构地区：[1]广东医学院附属医院肿瘤防治中心,广东省湛江市524001

出　　处：《中国肿瘤临床》2009年第7期365-367,共3页Chinese Journal of Clinical Oncology

基　　金：广东省湛江市科技攻关项目资助(编号:湛科[2005]82-25)

摘　　要：目的:探讨血清IL-18、IL-18BP的水平与原发性肝癌、良性肝肿瘤及肝硬化的发生、发展关系。揭示血清IL-18及IL-18BP在原发性肝癌诊断中的作用。方法:应用ELISA法检测原发性肝癌36例、良性肝肿瘤18例、肝硬化25例及正常人20例的血清IL-18及IL-18BP含量及原发性肝癌患者血中AFP的含量,比较各组间IL-18及IL-18BP含量的差别及原发性肝癌患者血AFP与IL-18、IL-18BP的关系。结果:原发性肝癌患者血清IL-18水平明显低于正常对照组、肝硬化组及良性肝肿瘤组,而血清IL-18BP的水平明显高于正常对照组、肝硬化组和良性肝肿瘤组,差异有显著性(P<0.001),且原发性肝癌组的血清IL-18及IL-18BP水平与其临床分期有密切联系:临床分期越晚,血清IL-18水平越低,血清IL-18BP水平越高;临床分期越低,血清IL-18水平越高,血清IL-18BP水平越低,差异有统计学意义(P<0.05或P<0.01)。另外,原发性肝癌患者的血清IL-18水平与AFP含量成负相关(r=-0.7152,n=36,P<0.01),血清IL-18BP的水平与AFP含量成正相关(r=0.6315,n=36,P<0.01);肝硬化患者、良性肝肿瘤患者血清IL-18及IL-18BP水平均明显高于正常人,差异有显著性(P<0.01)。结论:外周血IL-18及IL-18BP水平可反映原发性肝癌、良性肝肿瘤及肝硬化患者的免疫功能状态及原发性肝癌患者的临床分期,可作为原发性肝癌的辅助诊断及临床分期的有效指标,与AFP同时检测,可提高原发性肝癌的诊断符合率。Objective： To study the relationship of serum IL-18 and IL-18BP with the occurrence and development of primary liver cancer, benign liver tumor and liver cirrhosis and to investigate the role of serum IL-18 and IL-18BP detection in the diagnosis of primary liver cancer. Methods： The serum levels of IL-18 and IL-18BP in 36 patients with primary liver cancer, 18 patients with various benign liver tumor and 21 patients with liver cirrhosis were determined by IELISA assay. The levels of AFP in 36 patients with primary liver cancer were examined. The relationship among levels of serum IL-18 and IL-18BP and AFP in patients with primary liver cancer was explored. Results： The sIL-18 level in patients with primary liver cancer was significantly lower than that in the control groups and the patients with various benign liver tumor or LC. The sIL-18BP in patients with primary liver cancer was significantly higher than that in control groups and patients with various benign liver tumour or liver cirrhosis （P〈0.001）. The IL-18 and IL-18BP levels in patients with primary liver cancer was correlated with clinical stage. The sIL-18BP level in patients with primary liver cancer was correlated with AFP level （r=0.6315, n=36, P〈0.01）. The sIL-18 level in patients with primary liver cancer has minus relation to AFP level （r=-0.7152, n=36, P〈0.01）. The IL-18 and IL-18BP levels in patients with various benign liver tumor or liver cirrhosis was significantly higher than those in the controls （P〈0.05）. Conclusion： Serum levels of IL-18 and IL-18BP can reflect the immune function of patients with primary liver cancer or various benign liver tumor or liver cirrhosis and are helpful for diagnosis of primary liver cancer. Detecting AFP at the same time can increase the diagnostic accordance rate of primary liver cancer.

关 键 词：原发性肝癌肝硬化 良性肝肿瘤 白细胞介素18 白细胞介素18结合蛋白 

分 类 号：R735.7[医药卫生—肿瘤]