原发性胆汁肝硬化患者血清可溶性Fas和FasL的检测  

The detection of sFas and sFasL in serum of primary biliary cirrhosis patients

作　　者：杨红起[1] 曲少莲[1] 张炎芳[1] 王秀丽[1] 王际亮[1] 

机构地区：[1]胜利油田中心医院检验科,山东东营257034

出　　处：《医学检验与临床》2007年第6期46-47,共2页Medical Laboratory Science and Clinics

摘　　要：目的分析原发性胆汁肝硬化患者血清可溶性Fas和可溶性FasL水平情况,探讨其在发病机制中的作用。方法采用双抗体夹心酶联免疫吸附法(ELISA)法检测原发性胆汁性肝硬化患者20例,系统性红斑狼疮患者16例,HBsAg阳性患者26例,各项指标正常体检者24例。结果原发性胆汁性肝硬化(PBC)血清中的sFas明显高于HBsAg阳性患者和正常体检者(P<0.05),和系统性红斑狼疮患者无明显区别(P>0.05)。sFasL,PBC明显高于HBsAg+阳性患者(P<0.05)但与狼疮患者和正常体检者无明显区别(P>0.05)。结论对于原发性胆汁性肝硬化患者,sFas要比sFasL相对敏感。Objective To explore the pathogenesis role of sFas and sFasL in PBC patients by analysis of the level in serum.Methods 20 PBC,16 SLE,26 HBsAg+,24 Normal Control were studied.EIISA was used to detecte Fas and FasL in Serum.Results The level of sFas in serum from PBC is significantly higher than HBsAg+ and normal control group(p<0.05).compared with HBsAg+ group,the sFasl level PBC also obviously higher(p<0.05),but no difference between PBC and SLE or normal control group(p>0.05).Conclusion sFas is more sensive than sFasL for PBC.

关 键 词：原发性胆汁肝硬化 FAS SFAS 

分 类 号：R575.2[医药卫生—消化系统]