肺癌患者部分凝血及纤溶分子标志物的变化  

Variation of coagulation and fibrinolytic molecular markers in lung caner patients

作　　者：王朝春[1] 曹珉光[1] 

机构地区：[1]山东省济宁市第一人民医院检验科,济宁272100

出　　处：《医学检验与临床》2007年第2期41-42,共2页Medical Laboratory Science and Clinics

摘　　要：目的观察肺癌患者部分凝血及纤溶分子标志物的变化,以研究其与肺癌的发生,发展与止凝血的关系。方法检测65名肺癌患者(鳞癌38例、腺癌19,未分化癌8例),良性病变35例(结核13例,炎症20例)对照40例。检测项目为纤维蛋白原(Fbg)、D-二聚体D-dimer(D-D)、尿激酶型纤溶酶原激活物(u-PA)血浆含量。结果肺癌患者Fbg、D-D、u-PA明显高于良性病变及正常对照组,不同类型的肺癌之间,其上述指标无统计学差异,有周围脏器转移患者u-PA较未转移患者明显升高,Fbg,D-D无明显差异。结论肺癌患者存在着明显的凝血、纤溶激活状态。Fbg、D-D、u-PA可以作为肺癌患者诊断、鉴别诊断的辅助指标,u-PA对肺癌患者有无转移,有一定的辅助诊断意义。Objective To investigate the variation of coagulation and fibdnolytic molecular markers in lung cancer patiens and their relationship with tumor incidence and development.Methods The plasma leves of Fbg、D-D、u-PA were measured in 65 lung cancer.Results The plasma levels of Fbg、D-D,u-PA in lung cancer were significantly higher than that of normal contaols and pneumonia and pulmonary tuberculosis.However no significant difference between squamous cell carcinoma adenocarcinoma and undifferentiated carcinoma.Conclusions Activation of coagulation and fibrinolysis existedin lung cancer patients.Fbg、D-D,u-PA might also be clinical useful markers for lung cancer determination and prognosis.

关 键 词：肺癌 纤维蛋白原 尿激酶型纤溶酶原激活物 

分 类 号：R734.2[医药卫生—肿瘤]