转化生长因子β信号转导途径与胃癌发生发展的关系  

The relationship between TGF-βsignal transduction pathway and pathogenesis of gastric carcinoma

作　　者：郭建红[1] 马韬[2] 张云鹏[3] 董卫青 冯涛[3] 郭雅图 梁兴宇[3] 王超[3] 秦维山[3] 郭剑津[3] 

机构地区：[1]山西医科大学病理教研室,太原030001 [2]天津医科大学 [3]山西医科大学医疗系,太原030001

出　　处：《肿瘤研究与临床》2007年第3期185-187,共3页Cancer Research and Clinic

基　　金：山西医科大学学生创新项目基金资助课题(200402)

摘　　要：目的探讨转化生长因子β(TGF-β)信号转导途径与胃癌发生、发展的关系。方法应用免疫组织化学方法,检测26例正常胃黏膜、22例肠上皮化生、20例不典型增生及43例胃癌中TGF-β受体(RⅠ、RⅡ)和Smad4蛋白的表达。结果TGF-βRⅠ、TGF-βRⅡ和Smad4表达的阳性率随着胃组织病变程度的进展而降低(P<0.01)。TGF-βRⅠ在胃癌组织中的阳性表达与胃癌组织分化程度、浸润深度及有无淋巴结转移无关。胃癌组织TGF-βRⅡ和Smad4的阳性表达率随浸润深度的加深而降低,差异均有统计学意义(P<0.01,P<0.05);在淋巴结转移阳性患者TGF-βRⅡ、Smad4表达阳性率显著低于无淋巴结转移者,差异有统计学意义(P<0.05);TGF-βRⅡ和Smad4在中、高分化组中的阳性表达率明显高于低分化组(P<0.05)。结论TGF-β信号转导途径与胃癌发生、发展密切相关,其受体表达的缺失可能是肿瘤细胞逃逸TGF-β负调控的机制之一。Objective To study the relationship between TGF-βsignaling pathway and pathogenesis of gastric carcinoma.Methods The expression of TGF-βRⅠ,TGF-βRⅡand Smad4 protein was deter- mined by immunohistochemistry in normal gastric mucosa(26 cases),intestinal metaplasia(22 cases),dysplasia (20 cases)and gastric carcinoma(43 cases).Results The positive expression rate of TGF-βRⅠ,TGF-βRⅡand Smad4 decreased following the malignant degree in gastric tissues(P<0.01).The expression of TGF-βRⅠin gastric carcinoma was not correlated with differentiation,infiltrative deepness and lymph node metastasis. The expression level of TGF-βRⅡand Smad4 in well differentiated carcinoma was higher than that in poorly differentiated carcinoma(P<0.05).Also,the decreased expression of TGF-βRⅡand Smad4 was significantly correlated with lymph node metastasis and infiltrative deepness(P<0.05,P<0.01).Conclusion TGF-βsig- naling pathway is close correlated with pathogenesis of gastric carcinoma.The gastric carcinoma cell may es- cape the growth inhibitory effect of TGF-βbecause of loss expression of TGF-βreceptor.

关 键 词：胃肿瘤 转化生长因子Β 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]