依达拉奉对脑出血患者丙二醛超氧化物歧化酶的影响  

The influence of malondialdehyde and superoxide dismutase of edaravone on patients with intracranial hemor- rhage.

作　　者：宋钦[1] 张海欣[2] 顾俊琴[3] 胡磊[2] 

机构地区：[1]保定市第四医院神经内科,河北保定071051 [2]保定市第二医院神经内科,河北保定071051 [3]保定市儿童医院内五科,河北保定071051

出　　处：《中国实用内科杂志》2007年第S2期10-12,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的研究依达拉奉治疗脑出血时对丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。方法选择2006年1月至2007年9月保定市第二医院神经内科住院的100例患者,随机分为依达拉奉组52例和对照组48例,两组均予以常规治疗为基础,依达拉奉组再予以生理盐水150 mL+依达拉奉30 mg,每日2次静脉滴注,共10d,后改为每日1次静脉滴注,7 d 后停用。在治疗前及治疗后第4,7,14,21,28天采静脉血测定 MDA、SOD 浓度,进行治疗疗效评价。结果与治疗前比较,依达拉奉组治疗后第4,7,14,21,28天,MDA 较治疗前降低,P<0.01,与对照组比较,P<0.01;SOD 较治疗前升高,P<0.01,与对照组比较,P<0.01。在第28天时,两者处于稳定状态。结论依达拉奉降低脑出血患者的 MDA,升高 SOD,清除自由基,保护脑细胞,降低脑出血致残率。Objective To study the influence of malondialdehyde(MDA)and superoxide dismutase(SOD)of edaravone on patients with intracranial hemorrhage(ICH).Methods Within an open trial design,100 subjects with ICH received either 60～30 mg(52 subjects)of edaravone via intravenous drip or routine treatment(47 subjects).17 days of adminis- tration was follomed by a 30-day observation period and the effects of MDA and SOD was evaluated on the 30th day be- tween serum concentrations of MDA ,SOD were detected by venous blood sampling was taken before treatment and on the 4th,7th,14th,21th,28th day after treatment.Results The serum MDA level was raised before treatment and was de- creased on the 4th,7th,14th,21 th,28th day after treatment(P<0.01),and the concentration of SOD was decreased or raised respectively(P<0.01).It was P<0.01 as comparing with control.Conclusion Data from the present study sug- gest that edaravone is safe and may reduce the disablement rate of ICH by reducing MDA level and increasing the concen- tration of SOD,edaravone can protect the cerebral cells by clearing free radical.

关 键 词：依达拉奉 丙二醛 超氧化物歧化酶 脑出血 

分 类 号：R743.34[医药卫生—神经病学与精神病学]