Cdk4在宫颈癌和宫颈上皮内瘤组织中的表达  

Expression of Cdk4 in cervical carcinoma and cervical intraepithelial neoplasia

作　　者：郑晓娟 庞天云 邓飞 邹琳 李飞虹 胡新荣 

机构地区：[1]广东医学院病理学教研室 [2]广东医学院附属医院妇产科

出　　处：《广东医学院学报》2009年第1期17-19,共3页Journal of Guangdong Medical College

基　　金：湛江市科技招标项目(No.zz0405)

摘　　要：目的观察Cdk4在宫颈肿瘤发生发展中的表达情况。方法用免疫组织化学染色的方法对141例宫颈组织（19例慢性宫颈炎、15例低度宫颈上皮内瘤变、41例高度宫颈上皮内瘤变和66例宫颈浸润癌）进行检测，确定染色强度，计算阳性率并进行x^2检验分析。结果按照上述病变顺序，Cdk4染色强度由弱变强，阳性率由低到高，阳性率分别是21．1％、46．7％、73．2％、92．4％，经x^2检验，P〈0．01。结论Cdk4在宫颈肿瘤中的表达升高，与宫颈肿瘤的发生发展关系密切。Objective To investigate the expression of Cdk4 in the occurrence and development of cervical neoplasma. Methods Cdk4 expression was determined by immunohistochemical staining in 141 cervical specimens （chronic cervicitis, 19; low degree of intraepithelial neoplasia, 15; high degree of intraepithelial neoplasia, 41; invasive cervical cancer, 66）, and its positive rate and staining intensity were analyzed. Results Cdk4 expression rates in chronic cervicitis, low and high degree of intraepithelial neoplasia, and invasive cervical cancer were 21.1%, 46.7%, 73.2% and 92.4%, respectively. The positive rate and staining intensity of Cdk4 in cervical cancer were significantly higher than those in other lesions （P 〈 0.01 ）. Conclusion The expression of Cdk4 is upregulated in cervical cancer, which might be related to the occurrence and development of cervical tumor.

关 键 词：宫颈癌 宫颈上皮内瘤 CDK4 

分 类 号：R737.33[医药卫生—肿瘤]