难治性白血病中端粒酶活性与多药耐药及预后  

The relation of telomerase activity and multi-drug resistant with the prognosis in relapsed leukemia

作　　者：刘彦霞[1] 郭燕[2] 徐健[1] 

机构地区：[1]山东大学山东省立医院血液科,济南250021 [2]山东省千佛山医院血液科

出　　处：《白血病．淋巴瘤》2007年第6期430-432,共3页Journal of Leukemia & Lymphoma

摘　　要：目的探讨端粒酶活性(TA)与难治性白血病及其产生多药耐药(MDR)的关系。方法对29例难治性白血病患者进行体外药敏试验,制定个体化化疗方案,测定化疗前后的 TA。结果 29例患者TA 阳性率为75.86%;<40岁和≥40岁组患者的阳性率分别为66.7%和80%;AML-M_2患者的阳性率为75%。治疗前后 TA 阳性率比较,差异无统计学意义。<40岁组与≥140岁组的 TA 阳性率比较,差异也无统计学意义。结论端粒酶被激活是白血病的特征之一;难治性白血病患者中 TA 与年龄无相关性;复发难治性白血病患者中以 AML-M_2居多,可能与各亚型中以 M_(2a)活性最高以及具有高水平酶活性的白血病患者难以治疗有关;端粒酶持续高表达是 MDR 产生的原因之一。Objective In order to find out the relationship between telomerase activity(TA)and re- lapsed leukemia and multi-drug resistance.Methods Test the sensitivity of the 29 relapsed leukemia pa- tients to 10 chemotherapeutic agents;design personal chemotherapy programs;search the telomerase activities before and after chemotherapy.Results Among 29 relapsed leukemia patients,the positive rate of telomerase activities is 75.86 %.In the group younger than 40 s and the group older-than-40(including 40)the positive rates are 66.7 % and 80 % separately.By comparison there is not significant change in the positive rates of telomerase activity before and after the treatment,also no significant change between the group younger-than- 40 and older-than-40(including 40).Conclusion Telomerase-activated is one of the characters of the re- lapsed leukemia.Telomerase activity of the relapsed leukemia patients has no relationship with age.Among the relapsed patients types AML-M_2 is on the top,which seems to be relative with that it is M_(2a)whose activity is the highest one among the positive rates of TA in AML,and the patients with high TA are difficult to cure. Telomerase high-activated is one of the reasons to arouse drug-resistance.

关 键 词：白血病 端粒 末端转移酶 多药耐药相关蛋白质类 

分 类 号：R733.7[医药卫生—肿瘤]