原发性骨非霍奇金淋巴瘤10例  

Clinical analysis of primary non-Hodgkin lymphoma of bone:a report of 10 patients

作　　者：徐卫[1] 李建勇[1] 张苏江[1] 钱思轩[1] 程月新[1] 吴汉新[1] 陆化[1] 仇红霞[1] 盛瑞兰[1] 

机构地区：[1]南京医科大学第一附属医院,江苏省人民医院血液科210029

出　　处：《白血病．淋巴瘤》2007年第6期446-448,共3页Journal of Leukemia & Lymphoma

摘　　要：目的研究原发性骨非霍奇金淋巴瘤(PBL)的临床特征、治疗方法及其与预后的关系。方法回顾性分析经病理证实的10例 PBL 患者的临床资料和治疗效果,Kaplan-Meier 法分析患者生存期。结果 10例 PBL 患者的 X 线片中均有程度不同的溶骨性破坏;其中 B 细胞淋巴瘤8例,T 细胞淋巴瘤2例;治疗主要采用全身化疗和局部放疗。所有患者治疗后评价完全缓解5例,部分缓解2例,稳定2例,进展1例。中位生存期35.5(4～109)个月,2年生存率66.7%。结论 PBL 以 B 细胞多见,可侵犯到骨的任何部位,以长骨多见。治疗应以放化疗为主,是一种预后较好的淋巴瘤。Objective To investigate the clinical features of primary bone lymphoma(PBL).Methods Clinical data of 10 patients with pathologically confirmed PBL were analyzed retrospectively,and Kaplan- Meier was used for survival time.Results X-ray showed osteolysis in all 10 PBL patients.8 cases were B- cell lymphoma,and 2 were T-cell lymphoma.Local radiotherapy combined with chemotherapy was conducted. The complete remission rate was 50.0%,and the 2-year survival rate was 66.7%.Conclusion The PBL has been more characterized as diffuse large B-cell lymphoma as of primary non-Hodgkin lymphoma of bone.It can arise in any part of the skeleton,but long bones are the most common sites of presentation.The usual treatments are chemotherapy and local radiotherapy.The prognosis is better and it may he a cured disease.

关 键 词：淋巴瘤 非霍奇金 骨肿瘤 预后 

分 类 号：R738.1[医药卫生—肿瘤]