皮肤T细胞淋巴瘤及其归巢受体的研究进展  

Research progress of cutaneous T-cell lymphoma and homing receptor

作　　者：李占琦[1] 陈辉树[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院病理科,天津300020

出　　处：《白血病．淋巴瘤》2007年第4期305-308,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然基金资助项目(30571762)

摘　　要：介绍了皮肤T细胞淋巴瘤(cutaneous T-cell lymphoma,CTCL)归巢过程中的受体包括特异性受体如皮肤淋巴细胞相关抗原、趋化因子CCR4、CCR10,非特异性受体如选择素家族、整合素家族的相对分子质量等特性,并将近年来关于各类受体和它们与相关配体作用机制的研究进展作一综述,归巢受体的研究将为CTCL的靶向治疗提供理论依据,有利于改善患者的预后。In the text,the chemical peculiarity for homing receptor of cutaneous T-cell lymphoma (CTCL)is generalized,in which include specific receptor such as cutaneous lymphocyte-associated antigen, chemokineCCR4,CCR10,non-specific receptor such as selectin family,integrin family.The progress that the homing receptor of CTCL,relevant ligand and their action mechanism in recent years were summarized.The research of homing receptor will bring evidence for target therapy of CTCL and improve effect.

关 键 词：淋巴瘤 T细胞 皮肤 受体 淋巴细胞归巢 

分 类 号：R739.5[医药卫生—肿瘤]