FMD方案治疗惰性淋巴瘤的临床观察  

Clinical observation of first treating indolent non-Hodgkin lymphoma by FMD regimen

作　　者：陈恕之[1] 陈莉[2] 

机构地区：[1]南京医科大学第三附属医院血液肿瘤科,211900 [2]第二军医大学附属长海医院血液科

出　　处：《白血病．淋巴瘤》2007年第5期350-351,354,共3页Journal of Leukemia & Lymphoma

摘　　要：目的分析 FMD 方案初治惰性淋巴瘤的疗效及毒副作用。方法 24例确诊惰性淋巴瘤患者初治采用 FMD 方案:氟达拉滨(Flu)25～30 mg·m^(-2)·d^(-1),静脉滴注30 min,第1天至第3天;米托蒽醌(Mit)10mg·m^(-2)·d^(-1),静脉滴注30min,第1天;地塞米松(Dxm)40mg/d,静脉滴注,第1天至第5天。结果24例患者中,完全缓解(CR)54.1%,部分缓解(PR)29.1%,有效率为83.2%。主要毒副作用是骨髓抑制。结论 FMD 方案初治惰性淋巴瘤临床效果好,患者可以耐受,是一种安全有效的较理想的方案。Objective To discuss the therapeutic effect and toxicity of FMD regimen in initial un- treated patients with indolent non-Hodgkin lymphoma.Methods 24 initial untreated patients with indolent non-Hodgkin lymphoma were treated with FMD regimen:Fludarabine 25～30 mg/m^2 intravenously(Ⅳ)for 30 minutes days 1～3,Mitoxantrone 10mg/m^2 Ⅳ for 30 minutes day1,Dexamethasone 40 mg Ⅳ days 1～5.Re- sults Of the 24 patients,complete response(CR)rates were 54.1%,partial response rates were 29.1%,over- all response rates were 83.2%.The most common side effects were myelosuppression and immunosuppression. Conclusion The FMD regimen is a well-effective and tolerated treatment regimen for initial untreated pa- tients with indolent non-Hodgkin lymphoma.

关 键 词：淋巴瘤 非霍奇金 抗肿瘤联合化疗方案 

分 类 号：R733.1[医药卫生—肿瘤]