全反式维甲酸联合三氧化二砷治疗儿童急性早幼粒细胞白血病疗效观察  

Clinical observation of the efficacy of the treatment with combination of all-trans retinoic acid and arsenic trioxide in childhood acute promyelocytic leukemia

作　　者：程艳丽[1] 

机构地区：[1]山西省儿童医院血液科,太原030013

出　　处：《白血病．淋巴瘤》2007年第5期358-359,共2页Journal of Leukemia & Lymphoma

摘　　要：目的观察全反式维甲酸(ATRA)联合三氧化二砷(As_2O_3)治疗儿童初发急性早幼粒细胞白血病(APL)的疗效和不良反应。方法 ATRA 联合 As_2O_3治疗初发 APL 患儿16例。治疗方案:ATRA 25 mg·m^(-2)·d^(-1),分2～3次口服,As_2O_3 0.16 mg·kg^(-1)·d^(-1),加入生理盐水或50 g/L 葡萄糖溶液静脉滴注,持续4～6 h,1次/d。结果 14例患者获得完全缓解(CR),CR 率87.5%,CR 时间短,没有明显不良反应。结论 ATRA 联合 As_2O_3,治疗儿童 APL 能获得很好疗效。Objective To observe the efficacy and side effect of the all-trans retinoic acid(ATRA) and arsenic trioxide(As_2O_3)combination in acute promyelocytic leukemia(APL).Methods 16 APL patients were treated with the ATRA and As_2O_3 combination.The treatment protocol was as following:0.16 mg·kg^(-1)·d^(-1) As_2O_3 in 50g/L glucose solution or 9g/L natri-chloridi solution for intravenous drip over 4～6 hours once a day,ATRA was given 25 mg·kg^(-1)·d^(-1).Results 14 patients achieved complete remission(CR),the CR rate was 87.5%.No significant side effect was observed.Conclusion The ATRA and As_2O_3 in the treatment of APL can obtain a higher CR rate.

关 键 词：维甲酸 砷剂 白血病 早幼粒细胞 急性 儿童 疗效 

分 类 号：R733.71[医药卫生—肿瘤]