p53蛋白泛素化修饰的研究进展  

The Development of Ubiquitination

作　　者：赵蕾[1] 赵彦林[1] 赵士富[1] 

机构地区：[1]军事医学科学院放射医学研究所,中国北京100850

出　　处：《生命科学研究》2004年第S2期44-47,共4页Life Science Research

摘　　要：p53具有抑制肿瘤细胞增殖的作用,但是细胞内p53蛋白的堆积反而加速细胞衰老或凋亡,因此对p53进行严格的调控显得格外重要.泛素化、磷酸化和乙酰化是p53蛋白最主要的几种修饰形式,但近来研究表明泛素化对p53调控发挥着中心作用.MDM2是主要的负调节因子,其具有泛素连接酶的活性,早先的研究认为MDM2的作用主要是特异性结合p53并介导其在蛋白酶作用下降解,但近来的研究发现MDM2还可以介导p53的核-浆交换,这种现象在DNA损伤时尤为明显.推测MDM2介导p53的泛素化在体内可能发挥着多种调控功能.The p53 tumor suppressor exerts anti proliferative effects,including growth arrest,apoptosis,and cell senescence.Tight regulation of p53 activation is imperative for proventing tumorigenesis and maintain normal cell growth.Ubiquitination,phosphorylation and acetylation are main post translational modifications to p53 that affect its overall appearance and activity,but recent finding suggest that ubiquitination play the central role among these.p53 is regulated by the major negative factor MDM2,which has the activity of ubiquitin ligasing enzyme and induces p53 degradation through proteasome.Recent studies indicated that MDM2 mediated ubiquitination also regulates nuclear cytoplasmic trafficking of p53.many transcriptional factors regulate the MDM2 p53 pathway by direct or indirect pathway.

关 键 词：P53 泛素化 MDM2-p53通路调节 核输出 

分 类 号：R730.2[医药卫生—肿瘤]