Pharmacokinetics of lactosaminated recombinant human growti hormone in mice  

乳糖化重组人生长激素在小鼠体内的药物动力学(英文)

作　　者：李云春[1] 管昌田[1] 赵可清[2] 陈泽莲[3] 李铜铃 

机构地区：[1]四川大学华西医学中心附属第一医院核医学科,成都中国610041 [2]四川师范大学化学系,成都中国610066 [3]四川大学华西医学中心附属第一医院药剂科,成都中国610041 [4]四川大学华西医学中心附属第一医药学院,成都中国610041

出　　处：《Acta Pharmacologica Sinica》2001年第5期70-74,共5页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China,No 39670861

摘　　要：AIM: To study the pharmacokinetic characteristics of lactosaminated recombinant human growth hormone (hGH-L) in mice. METHODS: The biodistribution was studied with in vivo radioactive tracer technique. The pharmacokinetics was investigated by radioim-munoassy (RIA) method of hGH-L. The results were compared with that of recombinant human growth hormone (hGH). RESULTS:125I-hGH-L has remarkable livertaxis. The area under drug concentration-time curve (32686.9 μg-min·L-1) in blood and serum mean residence time(21. 4 min) of hGH-L are less than that of hGH (36913. 1 μg · min · L-1 and 24. 9 min) ( P < 0.05). In target organ liver, hGH-L distribution half life (1.8 min) and elimination half life (11.1 min) are shorter than that of hGH (2.1 min and 27.7 min) (P < 0.05). The area under drug concentration-time curve (17621.9μg · min · L-1) of hGH-L is bigger than that of hGH(12148.2 μg ·min · L-1) (P<0.05) in liver. CONCLUSION: The pharmacokinetic paramters of hGH-L has obvious advantage over that of hGH.目的:研究乳糖化基因重组人生长激素(hGH-L)在小鼠体内的药代动力学特征。方法:用放射性核素体内示踪技术研究体内分布。建立hGH-L放射免疫分析(RIA)方法,研究其药代动力学特征,并对比研究基因重组人生长激素(hGH)。结果:^(125)I-hGH-L具有明显的趋势肝性。hGH-L的血药时曲线下面积和在血清的平均驻留时间均小于hGH,P<0.01;而靶器官肝脏的hGH-L分布半衰期、消除半衰期小于hGH,P<0.05,其药时曲线下面积大于hGH,P<0.05。结论:hGH-L的药代动力学特征明显优于hGH。

关 键 词：SOMATOTROPIN PHARMACOKINETICS re- combinant proteins 

分 类 号：R96[医药卫生—药理学]