A new method of research on molecular evolution of proteinase superfamily  

作　　者：SUN Zhirong JI Xinglai HU Shengmin WANG Yu HE Fuchu 

机构地区：[1]Department of Biology,Tsinghua University,Beijing 100084,China [2]Radiate Medicine Institute,Academy of Military Medical Sciences,Beijing 100850,China

出　　处：《Chinese Science Bulletin》2001年第7期578-582,共5页

基　　金：in part by the NationalNatural Science Foundation of China (Grant Nos. 39730310 and 39980007).

摘　　要：The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned by the SSAP program of Orengo and Taylor to obtain evolutionary distances. The resulting evolutionary tree provides a topology graph that can reflect the evolution of structure and function of homology proteinase. Moreover, study on evolution of the serine proteinase superfamily can lead to better understanding of the relationship and evolutionary difference among proteins of the superfamily, and is of significance to protein engineering, molecular design and protein structure prediction. Structure alignment is one of the useful methods of research on molecular evolution of protein.The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned by the SSAP program of Orengo and Taylor to obtain evolutionary distances. The resulting evolutionary tree provides a topology graph that can reflect the evolution of structure and function of homology proteinase. Moreover, study on evolution of the serine proteinase superfamily can lead to better understanding of the relationship and evolutionary difference among proteins of the superfamily, and is of significance to protein engineering, molecular design and protein structure prediction. Structure alignment is one of the useful methods of research on molecular evolution of protein.

关 键 词：molecular evolution SSAP algorithm structure alignment EVOLUTIONARY tree SERINE PROTEINASE superfamily. 

分 类 号：Q55[生物学—生物化学]