Mechanism and kinetics for scavenging superoxide anion by progesterone  

作　　者：SONG Junfeng SHAO Yong GUO Wei 

机构地区：[1]Institute of Electroanalytical Chemistry,Northwest University,Xi’an 710069,China [2]Department of Merterial and Chemical Engineering,Sichuan Institude of Light Industry and Chemical Technology,Zigong 643033,China

出　　处：《Chinese Science Bulletin》2001年第2期117-121,共5页

基　　金：the National Natural Science Foundation of China (Grant No. 29875017).

摘　　要：The chemical reaction of progesterone with su-peroxide anion O2- in 0.1 mol/L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2- generation by synthesized glucocorticoids in mecha-nism, the function that progesterone scavenges O2- is as-cribed to that O2- directly oxidizes the C =C double bond conjugated with the carbonyl moiety of progesterone mole-cule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant obtained is308 L·mol-1·s-1.The chemical reaction of progesterone with superoxide anion O2.? in 0.1 mol/L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2.? generation by synthesized glucocorticoids in mechanism, the function that progesterone scavenges O2.? is ascribed to that O2.? directly oxidizes the C = C double bond conjugated with the carbonyl moiety of progesterone molecule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant obtained is 308 L · mol?1 · s?1.

关 键 词：superoxide PROGESTERONE SCAVENGING KINETICS anti-oxidation. 

分 类 号：R341[医药卫生—基础医学]