Effect of MTECl on the functional expression of TCRαβ^+3G11^-6C10^-CD4^+CD8^- thymocyte subset  

作　　者：GE Qing and CHEN WeifengDepartment of Immunology, Beijing Medical University, Beijing 100083, China Corresponding author 

出　　处：《Chinese Science Bulletin》1999年第17期1571-1576,共6页

摘　　要：A murine CD4+ thymocyte subset with phenotype of TCRαβ + 3G11- 6C10- CD4 + CD8- CD69 + /- HSAmed/lo contains the cells in relatively functional matured status. The functional property of the cells in this subset is characterized by the unique pattern of cytokine production at transitional stage from ThO to Th2 type with the latter being the dominant type. After being co-cultured with murine thymic medullary epithelial cell line (MTEC1) cells, a murineA murine CD4+ thymocyte subset with phenotype of TCRαβ + 3G11- 6C10- CD4 + CD8- CD69 +/- HSAmed/locontains the cells in relatively functional matured status. The functional property of the cells in this subset is characterized by the unique pattern of cytokine production at transitional stage from Th0 to Th2 type with the latter being the dominant type. After being co-cultured with murine thymic medullary epithelial cell line (MTEC1) cells, a murine thymic medullary type epithelial cell line, the TCRαβ(T 3G11 6C10-CD4 + CD8- CD69+/- HSAmed/l?thy-mocytes, has exhibited significantly higher levels of proliferation capability and IL-6 production, whereas the production of IL-4 and IL-10 is suppressed after co-culturing with MTECl. By contrast, MTECl could not induce thymocytes to secrete Th1 type of cytokines. The results suggest that MTECl can regulate functional status of this thymocyte subset and induce them to develop into a specialized Th2 subset.

关 键 词：TCRαβ⁺3G11^-6C10^-CD4⁺ CD8⁺ CD69^+/- HSA^med/lo THYMOCYTE SUBSET THYMIC STROMAL cells cytokine 

分 类 号：R392.1[医药卫生—免疫学]