THYMOCYTE

作品数:24被引量:42H指数:4
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相关领域:医药卫生更多>>
相关作者:龙建平更多>>
相关机构:中山医科大学西安电子科技大学浙江大学更多>>
相关期刊:《Chinese Medical Journal》《Science Bulletin》《Progress in Natural Science:Materials International》《Journal of Traditional Chinese Medicine》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市青年科技启明星计划更多>>
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Alterations in thymocyte populations under conditions of endotoxin tolerance
《Chinese Medical Journal》2021年第15期1855-1865,共11页Yi-Jing Tao Juan-Juan Zhao Li-Hua Rao Song Yang Guo-Liang Zhang Meng-Meng Guo Chao Chen Lin Xu 
the Project of the Guizhou Provincial Department of Science and Technology(No.QKH-JC-2018-1428);the National Natural Science Foundation of China(No.31760258);the Guizhou Province Graduate Research Fund(No.YJSCXJH-2020-093).
Background:Endotoxin tolerance(ET)is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide(LPS)leads to dramatically elevated survival.Accumulating evidence has shown that peripher...
关键词:Immune tolerance THYMOCYTES T-cell receptor Gene rearrangement Adaptive immunity 
Metabolic regulation of T cell development by Sinl-mTORC2 is mediated by pyruvate kinase M2被引量:4
《Journal of Molecular Cell Biology》2019年第2期93-106,共14页Xinxing Ouyang Yuheng Han Guojun Qu Man Li Ningbo Wu Hongzhi Liu Omotooke Arojo Hongxiang Sun Xiaobo Liu Dou Liu Lei Chen Qiang Zou Bing Su 
the National Natural Science Foundation of China (31470845, 81430033, and 31670896);Shanghai Science and Technology Commission (13JC1404700);Shanghai Rising-Star Program (16QA1403300).
Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and...
关键词:mT0RC2 Sinl THYMOCYTE development PPAR-Γ PKM2 METABOLISM 
Themis releases the brakes on TCR signaling during thymocyte selection by disabling SHP-1被引量:1
《Cellular & Molecular Immunology》2017年第9期724-726,共3页Laura Patrussi Cosima T Baldari 
In this issue of Nature Immunology,Choi and colleagues1 identify a key function of the T cell-specific protein thymocyte-expressed molecule involved in selection(THEMIS)in T cell development.They demonstrate that the ...
关键词:development. RELEASE SUSCEPTIBILITY 
Immunomodulation with rabbit anti-thymocyte globulin in solid organ transplantation
《World Journal of Transplantation》2015年第4期261-266,共6页Giovanbattista Ippoliti Marco Lucioni Giuseppe Leonardi Marco Paulli 
Rabbit anti-thymocyte globulin's manifold mechanisms of action may be attribuited to its polyclonal nature. Its T-cell depleting effect on lymphoid cells is well established: Occurring in the blood and secondary lymph...
关键词:RABBIT anti-thymocyte GLOBULIN Solid ORGAN TRANSPLANTATION Induction therapy IMMUNOMODULATION 
Two Cases of Refractory Large Granular Lymphocytic Leukemia Treated by Porcine Anti-human Thymocyte Immunoglobulin
《Chinese Medical Journal》2015年第5期709-710,共2页Qiang Zeng Hong Wang Hong Chang 
To the Editor:Large granular lymphocytic leukemia (LGLL) is a rare chronic clonal lymphoproliferative disease characterized by a persistent increase in large granular lymphocytes,which are large lymphocytes with a ...
Hemophagocytic lymphohistiocytosis: Recent progress in the pathogenesis, diagnosis and treatment被引量:5
《World Journal of Hematology》2014年第3期71-84,共14页Shinsaku Imashuku 
Hemophagocytic lymphohistiocytosis(HLH) is a hyperinflammatory syndrome that develops as a primary(familial/hereditary) or secondary(non-familial/hereditary) disease characterized in the majority of the cases by hered...
关键词:ALEMTUZUMAB Anti-thymocyte globulin Cyclosporine A Epstein-Barr virus Etoposide Hematopoietic STEM-CELL transplantation HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Hereditary diseases IMMUNOCHEMOTHERAPY Intravenous immunoglobulin Molecular diagnosis Rituximab Steroids 
Antithymocyte globulin/antilymphocyte globulin plus kidney-nourishing Chinese Medicinal:effect on severe aplastic anemia被引量:3
《Journal of Traditional Chinese Medicine》2012年第4期604-608,共5页Xudong Tang Feng Liu Liu Li Chi Liu Shanshan Zhang Haiyan Xiao Chunmei Zheng Shu Xu Rou Ma 
OBJECTIVE: To explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on se- vere aplastic anemia (SAA). METHODS: Twenty-five subjects...
关键词:Anemia  aplastic Reinforcing kidney Drugs  Chinese herbal Antilymphocyte serum Anti-thymocyte serum 
Intermittent Fasting Ameliorates Delayed-Type Hypersensitivity in NC/Nga Mice
《Food and Nutrition Sciences》2011年第4期287-293,共7页Hirao Kohno Katsuyasu Kouda Hiroyasu Ishihara Nobuhiro Nishio Yutaka Sasaki Harunobu Nakamura Masayuki Iki Yoshiaki Sonoda 
It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as mo...
关键词:INTERMITTENT FASTING Delayed-Type HYPERSENSITIVITY Contact DERMATITIS THYMOCYTE 
The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression被引量:2
《Cell Research》2010年第1期99-108,共10页Yonghao Cao Hai Li Haifeng Liu Chao Zheng Hongbin Ji Xiaolong Liu 
Acknowledgments We thank X Wu (Fudan University) for LckCre mouse and K Wong (Dana-Farber Cancer Institute) for LKB1 mouse, R Bosselut (National Institutes of Health) and D Li (Shanghai Institutes for Biological Sciences) for instructive comments on the manuscript; We are grateful to our colleagues F Liu for animal husbandry, W Bian for cell sorting and X Wang for real-time PCR analysis. This research was supported in part by the National Natural Science Foundation of China (30872290, 30925031), the Ministry of Science and Technology (2006CB504303, 2007CB815802, 2009ZX 10004-105), the Hi-Tech Research and Development Program of China (2007AA02Z167), the National Basic Research Program of China (2007CB914504) and the Chinese Academy of Sciences (KSCX 1-YW-R-43, KSCX2-YW-R-10).
LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity a...
关键词:LKB 1 AMPK BCL-XL THYMOCYTE SURVIVAL development 
Effect of N-acetylcysteine on 12C6+ Ion Irradiation-induced Splenic Lymphocyte DNA Damages, Serum Cytokine and Superoxide Dismutase, Thymocyte Cycle and Apoptosis Changes in Mice被引量:1
《近代物理研究所和兰州重离子加速器实验室年报:英文版》2009年第1期167-168,共2页Xie Yi Zhang Hong Liu Yang Hao Jifang Zhao Weiping Wu Zhenhua Qiu Rong 
关键词:重离子辐射 超氧化物歧化酶 脾淋巴细胞 DNA损伤 辐照诱导 半胱氨酸 细胞凋亡 细胞周期 
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