the Project of the Guizhou Provincial Department of Science and Technology(No.QKH-JC-2018-1428);the National Natural Science Foundation of China(No.31760258);the Guizhou Province Graduate Research Fund(No.YJSCXJH-2020-093).
Background:Endotoxin tolerance(ET)is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide(LPS)leads to dramatically elevated survival.Accumulating evidence has shown that peripher...
the National Natural Science Foundation of China (31470845, 81430033, and 31670896);Shanghai Science and Technology Commission (13JC1404700);Shanghai Rising-Star Program (16QA1403300).
Glucose metabolism plays a key role in thymocyte development. The mammalian target of rapamycin complex 2 (mT0RC2) is a critical regulator of cell growth and metabolism, but its role in early thymocyte development and...
In this issue of Nature Immunology,Choi and colleagues1 identify a key function of the T cell-specific protein thymocyte-expressed molecule involved in selection(THEMIS)in T cell development.They demonstrate that the ...
Rabbit anti-thymocyte globulin's manifold mechanisms of action may be attribuited to its polyclonal nature. Its T-cell depleting effect on lymphoid cells is well established: Occurring in the blood and secondary lymph...
To the Editor:Large granular lymphocytic leukemia (LGLL) is a rare chronic clonal lymphoproliferative disease characterized by a persistent increase in large granular lymphocytes,which are large lymphocytes with a ...
Hemophagocytic lymphohistiocytosis(HLH) is a hyperinflammatory syndrome that develops as a primary(familial/hereditary) or secondary(non-familial/hereditary) disease characterized in the majority of the cases by hered...
OBJECTIVE: To explore the effect of antithymocyte globulin (ATG)/antilymphocyte globulin (ALG) plus kidney-nourishing Chinese medicinal (KNCM) on se- vere aplastic anemia (SAA). METHODS: Twenty-five subjects...
It is well documented that dietary restriction can prevent many different diseases and extend the life spans of different rodent species. In the previous study, we reported that intermittent fasting (IF) as well as mo...
Acknowledgments We thank X Wu (Fudan University) for LckCre mouse and K Wong (Dana-Farber Cancer Institute) for LKB1 mouse, R Bosselut (National Institutes of Health) and D Li (Shanghai Institutes for Biological Sciences) for instructive comments on the manuscript; We are grateful to our colleagues F Liu for animal husbandry, W Bian for cell sorting and X Wang for real-time PCR analysis. This research was supported in part by the National Natural Science Foundation of China (30872290, 30925031), the Ministry of Science and Technology (2006CB504303, 2007CB815802, 2009ZX 10004-105), the Hi-Tech Research and Development Program of China (2007AA02Z167), the National Basic Research Program of China (2007CB914504) and the Chinese Academy of Sciences (KSCX 1-YW-R-43, KSCX2-YW-R-10).
LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity a...