ALEMTUZUMAB

作品数：22被引量：22H指数：4
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相关领域：医药卫生更多>>
相关作者：周颖蔡清清卜庆林旭滨高岩更多>>
相关机构：中山大学中国人民解放军南京大学中国医学科学院北京协和医学院更多>>
相关期刊：《Cellular & Molecular Immunology》《药学进展》《World Journal of Hematology》《中华医学信息导报》更多>>
相关基金：国家重点基础研究发展计划国家自然科学基金国家科技支撑计划更多>>
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Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol被引量：4
《World Journal of Transplantation》2017年第1期34-42,共9页Michelle Willicombe Anna Rizzello Dawn Goodall Vassilios Papalois Adam G Mc Lean David Taube 
AIM To analyse the risk factors and outcomes of delayed graft function(DGF) in patients receiving a steroid sparing protocol. METHODS Four hundred and twenty-seven recipients of deceased donor kidney transplants were ...
关键词：ALLOGRAFT failure Deceased DONORS Delayed graft function Cold ISCHAEMIC time Rejection STEROID sparing ALEMTUZUMAB 
Effect of Alemtuzumab on Intestinal Intraepithelial Lymphocytes and Intestinal Barrier Function in Cynomolgus Model被引量：4
《Chinese Medical Journal》2015年第5期680-686,共7页Lin-Lin Qu Ya-Qing Lyu Hai-Tao Jiang Ting Shan Jing-Bin Zhang Qiu-Rong Li Jie-Shou Li 
This work was supported by grants from the National Basic Research Program （973 Program） in China （No. 2007CB513005 and 2009CB522405）, Shangdong Province Young and Middle-Aged Scientists Research Awards Fund （No. BS2011YY004）, the Key Project of National Natural Science Foundation in China （No. 30830098）, National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science and Technology of China （No. 2008BAI60B06）, the National Natural Science Foundation in China （No. 3067206t）, the Military Scientitle Research Fund （No. 0603AM 117） and the Gut Barrier Foundation of Jie-Shou Li Academician.
Background：Alemtuzumab has been used in organ transplantation and a variety of hematologic malignancies （especially for the treatment of B-cell chronic lymphocytic leukemia）.However,serious infectious complications...
关键词：ALEMTUZUMAB Barrier Function INFECTION Intestinal lntraepithelial Lymphocytes Lymphocyte Depletion 
Pancreas transplantation: The Wake Forest experience in the new millennium
《World Journal of Diabetes》2014年第6期951-961,共11页Jeffrey Rogers Alan C Farney Giuseppe Orlando Samy S Iskandar William Doares Michael D Gautreaux Scott Kaczmorski Amber Reeves-Daniel Amudha Palanisamy Robert J Stratta 
AIM: To investigate the Wake Forest experience with pancreas transplantation in the new millennium with attention to surgical techniques and immunosuppression. METHODS: A monocentric, retrospective review of outcomes ...
关键词：ALEMTUZUMAB Mycophenolate mofetil Pancreas transplantation Portal-enteric Rabbit anti-thymocyte globulin Simultaneous kidney-pancreas transplantation Solitary pancreas transplantation Steroid elimination Surveillance biopsy TACROLIMUS 
Hemophagocytic lymphohistiocytosis: Recent progress in the pathogenesis, diagnosis and treatment被引量：5
《World Journal of Hematology》2014年第3期71-84,共14页Shinsaku Imashuku 
Hemophagocytic lymphohistiocytosis(HLH) is a hyperinflammatory syndrome that develops as a primary(familial/hereditary) or secondary(non-familial/hereditary) disease characterized in the majority of the cases by hered...
关键词：ALEMTUZUMAB Anti-thymocyte globulin Cyclosporine A Epstein-Barr virus Etoposide Hematopoietic STEM-CELL transplantation HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Hereditary diseases IMMUNOCHEMOTHERAPY Intravenous immunoglobulin Molecular diagnosis Rituximab Steroids 
Alemtuzumab: A Place in Therapy for Treatment of Multiple Sclerosis
《International Journal of Clinical Medicine》2013年第10期459-471,共13页Teya M. Tietje Douglas R. Allington Michael P. Rivey 
Alemtuzumab is a humanized mononclonal antibody known to cause rapid depletion of B-and T-cell lymphocytes. Subsequent repletion of these lymphocytes leads to changes in adaptive immunity. Alemtuzumab is approved by t...
关键词：ALEMTUZUMAB Multiple SCLEROSIS MONOCLONAL ANTIBODY LYMPHOCYTE Depletion 
单克隆抗体治疗急性淋巴细胞白血病
《国际输血及血液学杂志》2012年第5期424-428,共5页章艳茹(综述) 邱录贵(审校) 
国家科技支撑计划（2008BA161B01）,中瑞国际合作（天津）子课题（09ZCZDSF03800）
近年来，肿瘤细胞的单克隆抗体靶向杀伤已成为肿瘤治疗的发展趋势之一。譬如急性淋巴细胞白血病（ALL）细胞表面表达各种特异性抗原CD19，CD20，CD22和CD52等，引发了以这些靶点为目标的新型药物研发。现将就blinatumomab，利妥昔单抗（...
关键词：急性淋巴细胞白血病 单克隆抗体 CD19 CD20 CD22 CD52 blinatumomab RITUXIMAB EPRATUZUMAB inotuzumab ozogamicin ALEMTUZUMAB 
多发性硬化症治疗药Alemtuzumab的Ⅲ期临床研究又获新数据
《药学进展》2012年第5期237-237,共1页
本刊曾在2011年第11期上刊登过一则有关多发性硬化症（MS）治疗药——抗CD52单抗alemtu—zumab（专利名：Lemtrada^TM）的Ⅲ期临床研究获得阳性结果的报道。Genzyme公司近日在第64届美国神经病学学会（AAN）年会上公布了本品在该项名为C...
关键词：ALEMTUZUMAB 抗CD52单克隆抗体 多发性硬化症 
Antibody induction therapy in adult kidney transplantation: A controversy continues被引量：1
《World Journal of Transplantation》2012年第2期19-26,共8页Kanwaljit K Chouhan Rubin Zhang 
Antibody induction therapy is frequently used as an adjunct to the maintenance immunosuppression in adult kidney transplant recipients. Published data support antibody induction in patients with immunologic risk to re...
关键词：Induction Kidney TRANSPLANT THYMOGLOBULIN BASILIXIMAB ALEMTUZUMAB Acute REJECTION GRAFT survival 
多发性硬化症治疗药Alemtuzumab的Ⅲ期临床试验获阳性结果
《药学进展》2011年第11期514-514,共1页邢爱敏 
赛诺菲公司的下属公司Genzyme近日宣布,Genzyme公司和拜耳公司共同开发的人源单克隆抗体alemtuzumab的一项名为CARE-MSⅡ的Ⅲ期临床研究获得阳性结果,两项主要考察指标达到预期。
关键词：ALEMTUZUMAB 多发性硬化症 干扰素β-1a 
The response of intestinal stem cells and epithelium after alemtuzumab administration
《Cellular & Molecular Immunology》2011年第4期325-332,共8页Qiurong Li Qiang Zhang Chenyang Wang Shaojun Jiang Ning Li Jieshou Li 
the National Basic Research Program(973 Program)in China(nos.2009CB522405 and 2007CB513005);the Key Project of National Natural Science Foundation in China(30830098);the National Natural Science Foundation in China(81070375);the Scientific Research Fund in Jiangsu Province(BK2009317);the National Key Project of Scientific and Technical Supporting Programs Funded by the Ministry of Science and Technology of China(2008BAI60B06);the Military Scientific Research Fund(0603AM117).
Qiurong Li1,Qiang Zhang1,Chenyang Wang1,Shaojun Jiang2,Ning Li1,Jieshou Li1 Intestinal stem cells may have important roles in the maintenance of epithelial integrity during tissue repair.Alemtuzumab is a humanized ant...
关键词：ALEMTUZUMAB intestinal stem cells intestinal stem cell marker MUSASHI-1 LGR5 
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