MONOCLONAL

作品数：442被引量：816H指数：14
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相关机构：中南大学中山医科大学浙江大学医学院附属第二医院山东省寄生虫病防治研究所更多>>
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Approved delivery strategies for biopharmaceuticals
《Chinese Chemical Letters》2025年第2期41-51,共11页Makhloufi Zoulikha Zhongjian Chen Jun Wu Wei He 
supported by the National Natural Science Foundation of China(Nos.82073782 and 82241002);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(No.21KJA320003);the Scientific Research Project of Jiangsu Commission of Health(No.LKZ2023001)。
In recent years,biopharmaceuticals have witnessed remarkable advancements,transforming the landscape of therapeutic interventions.Biopharmaceuticals encompassing therapeutics generated through cutting-edge biotechnolo...
关键词：BIOPHARMACEUTICALS Nucleic acids Monoclonal antibodies PROTEINS Drug delivery 
Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow
《Research》2024年第4期442-457,共16页Xueping Chen Ke Fan Jun Lu Sheng Zhang Jianhua Dong Jisheng Qin Weihua Fan Yan Wang Yiyuan Zhang Huo Peng Zhizhong Zhang Zhiyong Sun Chunlai Yu Yucui Xiong Yan Song Qingqing Ye Shiwen Mai Yuanhua Wang Qizheng Wang Fengxiang Zhang Xiaohui Wen Tiancheng Zhou Li Han Mian Long Guangjin Pan Julian F.Burke Xiao Zhang 
funded by the Key Project for Instrument Development Program-Ministry of Finance[Grant No.ZDYZ2012-3];Operational Support Project of Instrument Development-Chinese Academy of Sciences[Grant No.1187000169];Project of Automated Stem Cell Induction and Culture Instrument Development-Chinese Academy of Sciences[Grant No.1187000170];Scientific Instrument Development Program-Chinese Academy of Sciences[Grant Nos.ZDKYYQ20210006 and YJKYYQ20210042];Key Research Program of Chinese Academy of Sciences[Grant No.O2222001];Guangdong Basic and Applied Basic Research Foundation[Grant No.2022A1515110435];Guangzhou Basic and Applied Basic Research Project[Grant No.2023A04J0107];Project funded by China Postdoctoral Science Foundation[Grant No.2021M693192];Guangdong International Scientific Research Cooperation Project[Grant No.2022A0505050037];Science and Technology Planning Project of Guangdong Province[Grant No.2023B1212060050].
Somatic cell reprogramming generates induced pluripotent stem cells(iPSCs),which serve as a crucial source of seed cells for personalized disease modeling and treatment in regenerative medicine.However,the process of ...
关键词：PROGRAMMING thereby PURITY 
The New Era for Respiratory Syncytial Virus Prevention for Infants in China:A Pediatricians’Perspective
《Infectious Diseases & Immunity》2024年第4期152-155,共4页Lisu Huang Zhimin Chen Mei Zeng 
supported by the Shanghai municipal three-year action plan for strengthening the construction of the public health system(2023-2025)GWVI-2.1.2.
This year marks a new era for respiratory syncytial virus(RSV)prevention for infants in China,as it is the first time since the detection of RSV that we have an option,namely,the long-acting monoclonal antibody nirsev...
关键词：PREVENTION RESPIRATORY MONOCLONAL 
2D4,a humanized monoclonal antibody targeting CD132,is a promising treatment for systemic lupus erythematosus
《Signal Transduction and Targeted Therapy》2024年第12期5693-5707,共15页Huiqi Yin Liming Li Xiwei Feng Zijun Wang Meiling Zheng Junpeng Zhao Xinyu Fan Wei Wu Lingyu Gao Yijing Zhan Ming Zhao Qianjin Lu 
supported by following fundings:the National Key R&D Program of China(No.2022YFC3601800);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059);non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RC320-001,No.2020-RC320-003);the Special Program of National Natural Science Foundation of China(NO.32141004);the Special Research Fund for Central Universities,Peking Union Medical College(No.3332023075);Natural Science Foundation of Jiangsu Province(No.BK20230130);National Natural Science Foundation of China(No.82302982).
Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness.To address this limitation,our focus was on CD132,a subunit common to six inflammatory fact...
关键词：CD13 LUPUS ERYTHEMATOSUS 
Systemic lupus erythematosus therapeutic strategy: From immunotherapy to gut microbiota modulation被引量：2
《Journal of Biomedical Research》2024年第6期531-546,共16页Vitaly Chasov Ekaterina Zmievskaya Irina Ganeeva Elvina Gilyazova Damir Davletshin Maria Filimonova Aygul Valiullina Anna Kudriaeva Emil Bulatov 
funded by the Russian Science Foundation Grant No.21-74-10154 to A.K.
Systemic lupus erythematosus(SLE)is characterized by a systemic dysfunction of both the innate and adaptive immune systems,leading to an attack on healthy tissues of the body.During the development of SLE,pathogenic f...
关键词：systemic lupus erythematosus IMMUNOTHERAPY monoclonal antibodies bispecific antibodies chimeric antigen receptor T cell fecal microbiota transplantation 
Leukocyte immunoglobulin‐like receptor B4:A keystone in immune modulation and therapeutic target in cancer and beyond
《Cancer Innovation》2024年第6期29-41,共13页Qi Liu Yuyang Liu Zhanyu Yang 
Leukocyte immunoglobulin‐like receptor B4(LILRB4)significantly impacts immune regulation and the pathogenesis and progression of various cancers.This review discusses LILRB4's structural attributes,expression pattern...
关键词：cancer therapy immune checkpoint immunotherapy leukocyte immunoglobulin‐like receptor B4 monoclonal antibodies 
“Small is beautiful”-Examining reliable determination of low-abundant therapeutic antibody glycovariants
《Journal of Pharmaceutical Analysis》2024年第10期1435-1449,共15页Katharina Böttinger Christof Regl Veronika Schäpertöns Erdmann Rapp Therese Wohlschlager Christian G.Huber 
Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy,and therefore,their reliable detection and quantification is essential.Our study introduces a multi-level quantification a...
关键词：GLYCOSYLATION Mass spectrometry Monoclonal antibodies Abundance profiling Minor glycovariants Multi-level analysis Data integration 
Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu 
supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。
Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...
关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES 
Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes
《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu 
the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.
The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...
关键词：ANTIBODIES inhibited MONOCLONAL 
DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice
《Genes & Diseases》2024年第4期368-380,共13页Dafei Chai Xu Wang Praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li 
supported by the Cancer Prevention and Research Institute of Texas(No.RR190043).
tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense mutant.However,there are currently no approved targeted therapies or immunotherapies against mutant ...
关键词：BsAb Cytotoxicity MAB Mutant p53 PD-1 R175H 
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