EPITOPES

作品数：96被引量：141H指数：7
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相关作者：郭礼和费俭夏国宏邢力叶欣更多>>
相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>
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Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1
《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu 
supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。
Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...
关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES 
Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes
《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu 
the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.
The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...
关键词：ANTIBODIES inhibited MONOCLONAL 
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents
《Signal Transduction and Targeted Therapy》2024年第7期2984-2998,共15页Xin Wang Jie Zhang Maoshun Liu Yuanyuan Guo Peipei Guo Xiaonan Yang Bingli Shang Min Li Jinmin Tian Ting Zhang Xi Wang Ronghua Jin Jikun Zhou George F.Gao Jun Liu 
supported by the National Key Research and Development Program of China(2022YFC2604100 to J.L.,and 2023YFC2306003 to X.W.);the National Natural Science Foundation of China(grants 92269203).
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic.However,the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity in...
关键词：IMMUNITY CONSERVED assessed 
Recent advances in the study of epitopes,allergens and immunologic cross-reactivity of edible mango
《Food Science and Human Wellness》2024年第3期1186-1194,共9页Honglei Guo Yanjun Cong 
supported by National Science and Technology Major Project of China (2019YFC1605002);National Natural Science Foundation of China (31872886)。
Mango(Mangifera indica L.)is a tropical fruit that is widely consumed as both fresh fruits and processed products around the world.The high incidence of mango allergy,on the other hand,has sparked widespread concern.T...
关键词：MANGO ALLERGEN EPITOPE Immunocross-reactivity Prospects 
Immunoinformatics assisted design of a multi-epitope kit for detecting Cronobacter sakazakii in powdered infant formula
《Food Quality and Safety》2024年第2期322-333,共12页Elijah K.Oladipo Olukayode I.Obisanya Victoria O.Owoeye Oyinlola G.Shittu Mautin G.Adamitonde Emmanuel C.Ikwuka Solomon O.Ojewale Adewale J.Tijani Feranmi A.Adedokun Amudatu A.Adedokun Temitope A.Oyedepo Helen Onyeaka 
Objectives:Cronobacter sakazakii,formerly Enterobacter sakazakii,is an emerging ubiquitous and opportunistic foodborne pathogen with a high mortality rate.It has been implicated in cases of meningitis,septicaemia,and ...
关键词：Powdered infant formula Cronobacter sakazakii BIOINFORMATICS IMMUNOINFORMATICS detection kit peptide-based EPITOPES analytical kits recombinant fusion protein PEPTIDES 
A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test
《Biosafety and Health》2024年第3期143-152,共10页Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi Zhen Zhang Ziquan Lv Qiuying Lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang 
the Key Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324115411030);Natural Science Foundation of China(92169102);R&D Program of Guangzhou Laboratory(SRPG22-006);Sanming Project of Medicine in Shenzhen(SZSM202211023);GuangDong Basic and Applied Basic Research Foundation(2022B1515120043);the Open Project Fund of Guangdong Provincial People’s Hospital(YKY-KF202208);National Natural Science Foundation of China(81902097);Funding by Science and Technology Projects in Guangzhou(SL2023A04J01160);the Guangdong Basic and;Applied Basic Research Foundation(2023A1515140117);the fellowship of China Postdoctoral Science Foundation(2023TQ0136,2023M741379);supported by grants from the National Key Research and Development Plan(2023YFE0118700,2021YFC2301604);the Fundamental Research Funds for the Central Q4 Universities(21623406).
Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coro...
关键词：Asymptomatic coronavirus disease 2019 (COVID-19) EPITOPES Specific CD8^(+)T cell ELISPOT 
Antigen epitopes of animal coronaviruses:a mini-review
《Animal Diseases》2024年第1期19-26,共8页Mingjun Su Guanghui Zheng Xiangwen Xu Houhui Song 
supported by the Natural Science Foundation of Zhejiang Province(Q23C180006);the Zhejiang A&F University Talent Initiative Project(118-203402005901).
Coronaviruses are widespread in nature and can infect mammals and poultry,making them a public health concern.Globally,prevention and control of emerging and re-emerging animal coronaviruses is a great challenge.The m...
关键词：Animal coronavirus Antigen epitope B-cell epitope T-cell epitope Immune responses Vaccines 
Cytological evaluation by Caco-2 and KU812 of non-allergenic peptides from simulated digestion of infant formula in vitro被引量：1
《Food Science and Human Wellness》2023年第3期817-824,共8页Zihao Xu Hao Bai Xin Ma Yong Wu Zhihua Wu Anshu Yang Weixiang Mao Xin Li Hongbing Chen 
supported by National Key R&D Program of China(2018YFC1604205);the National Natural Science Foundation of China(31760431);State Key Laboratory of Food Science and Technology,Nanchang University(SKLF-ZZA-201912)。
Milk allergy is a common allergic reaction found in infants and young children,most of them appear tolerance after growing up.In this study,infant formula was digested by simulated in vitro digestion method.The potent...
关键词：Milk allergy EPITOPES PEPTIDES Hypoallergenic Immune tolerance 
The amino acids differences in epitopes may promote the different allergenicity of ovomucoid derived from hen eggs and quail eggs
《Food Science and Human Wellness》2023年第3期861-870,共10页Mengzhen Hao Shuai Yang Shiwen Han Huilian Che 
supported by the Beijing Municipal Natural Science Foundation of China(7202100)。
Quail egg ovomucoid can inhibit activation of basophils and eosinophils,while hen egg ovomucoid has been shown to be a major allergen,named Gal d 1.At present,the differences in structure and function between two ovom...
关键词：Quail egg Hen egg OVOMUCOID Epitope DEGRANULATION 
Purification and immunoglobulin E epitopes identification of low molecular weight glutenin:an allergen in Chinese wheat
《Food Science and Human Wellness》2023年第3期720-727,共8页Yanbo Wang Yihang Tong Jinru Zhou Dong Yang Linglin Fu 
financially supported by the State Key Research and Development Plan(2019YFC1605002)。
As one of the most important cereals,wheat(Triticum aestivum)has high nutritional value and is widely cultivated in China.However,wheat can cause severe allergic reactions,and a growing number of people are developing...
关键词：Triticum aestivum ALLERGEN Low molecular weight glutenin(LMW-GS) Immunological tools 
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