EPITOPE

作品数：184被引量：373H指数：9
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相关机构：中山大学南京农业大学江苏省农业科学院华中师范大学更多>>
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A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy
《Acta Pharmaceutica Sinica B》2024年第11期4806-4818,共13页Xiaozhi Xi Yanqing Wang Guiqi An Shitao Feng Qiumei Zhu Zhongqiu Wu Jin Chen Zhicheng Zuo Qiang Wang Ming-Wei Wang Yuchao Gu 
Qingdao Marine Science and Technology Center(No.2022QNLM030003-4 and 8-01,China);Program of National Natural Science Foundation of China(No.82273846);Taishan Scholars Program(No.tsqn202211058,China).
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 has emerged as a promising target for antibody-drug conjugates (...
关键词：Shark VNAR IMMUNOTOXINS TROP-2Epitope identification ANTI-TUMOR Pseudomonas exotoxin A NANOBODY Breast cancer 
A multi-center study on genetic variations in the fusion protein of respiratory syncytial virus from children with Acute Lower Respiratory Tract Infections in China during 2017-2021
《Virologica Sinica》2024年第5期727-736,共10页Yiliang Fu Fei Li Yun Zhu Luci Huang Qiuping Li Hanwen Zhang Lili Zhong Hailin Zhang Zheng-xiu Luo Gen Lu Jikui Deng Lingfeng Cao Ying Wu Rong Jin Lei Li Lili Xu Xiangpeng Chen Zhengde Xie 
supported by the National Key Research and Development Program of China(grant number 2023YFC2306002);National Science and Technology Major Projects(grant number 2017ZX10104001-005-010);CAMS Innovation Fund for Medical Sciences(CIFMS)(Grant Number 2019-I2M-5-026);Funding for Reform and Development of Beijing Municipal Health Commission.
Respiratory syncytial virus(RSV)is a significant cause of acute lower respiratory tract infection(ALRTI)in children underfive years of age.Between 2017 and 2021,396 complete sequences of the RSV F gene were obtained fro...
关键词：Human respiratory syncytial virus(RSV) CHILDREN Fusion glycoprotein Antigenic epitope VARIATION 
Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope
《Signal Transduction and Targeted Therapy》2024年第9期3566-3568,共3页Qianhui Zhu Pan Liu Shuo Liu Can Yue Xiangxi Wang 
supported by Ministry of Science and Technology of China(CPL-1233 and SRPG22-003);National Key Research and Development Program(2018YFA0900801);CAS(YSBR-010);National Natural Science Foundation of China(NSFC)(32200138);the National Science Foundation Grants(12034006,32325004 and T2394482);supported by National Science Fund for Distinguished Young Scholar(No.32325004);the NSFS Innovative Research Group(No.81921005).
Dear Editor,Multiple waves of outbreaks of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)have resulted in unprecedented public health and socioeconomic crises.After 4 years of primary as well as breakthro...
关键词：properties acute respiratory 
DNA-delivered monoclonal antibodies targeting the p53 R175H mutant epitope inhibit tumor development in mice
《Genes & Diseases》2024年第4期368-380,共13页Dafei Chai Xu Wang Praveen Neeli Shan Zhou Xingfang Yu Kanaga Sabapathy Yong Li 
supported by the Cancer Prevention and Research Institute of Texas(No.RR190043).
tThe tumor suppressor p53 is the most common mutated gene in cancer,with the R175H as the most frequent p53 missense mutant.However,there are currently no approved targeted therapies or immunotherapies against mutant ...
关键词：BsAb Cytotoxicity MAB Mutant p53 PD-1 R175H 
Two nanobody‑based immunoassays to differentiate antibodies against genotype 1 and 2 porcine reproductive and respiratory syndrome virus
《Animal Diseases》2024年第2期98-114,共17页Xu Chen Yueting Chang Lu Zhang Xinyu Zhao Zhihan Li Zhijie Zhang Pinpin Ji Qingyuan Liu Jiakai Zhao Jiahong Zhu Baoyuan Liu Xinjie Wang Yani Sun Qin Zhao 
funded by grants from the National Key R&D Program of China(2023YFD1800304);the National Natural Science Foundation of China to QZ(32273041);the Natural Science Foundation of Shaanxi Province of China(2022JC-12);the Central Public-interest Scientific Institution Basal Research Fund,National Data Center of Animal Health.
Porcine reproductive and respiratory syndrome virus(PRRSV)infection causes significant economic loss to the global pig industry.Genotype 1 and 2 PRRSV(PRRSV-1 and-2)infections have been reported in China,Europe and Am...
关键词：PRRSV Competitive ELISA NANOBODY Antigen epitope 
Decoding bovine coronavirus immune targets:an epitope informatics approach
《Animal Diseases》2024年第2期138-153,共16页Swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa Suresh Jayashree Anandakumar Nagendra Nath Barman Sheethal Manjunath Yamini Sri S Sharanagouda S.Patil 
Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle populations.This necessitates the development of efficacious vaccines...
关键词：IMMUNOINFORMATICS Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning 
Recent advances in the study of epitopes,allergens and immunologic cross-reactivity of edible mango
《Food Science and Human Wellness》2024年第3期1186-1194,共9页Honglei Guo Yanjun Cong 
supported by National Science and Technology Major Project of China (2019YFC1605002);National Natural Science Foundation of China (31872886)。
Mango(Mangifera indica L.)is a tropical fruit that is widely consumed as both fresh fruits and processed products around the world.The high incidence of mango allergy,on the other hand,has sparked widespread concern.T...
关键词：MANGO ALLERGEN EPITOPE Immunocross-reactivity Prospects 
Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain
《Signal Transduction and Targeted Therapy》2024年第6期2726-2737,共12页Bo Liu Honghui Liu Pu Han Xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang 
supported by the National Key R&D Program of China(2022YFC2303403);the National Science Fund for Distinguished Young Scholars(82225021);supported by the Young Scientists in Basic Research(YSBR-010).
Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging...
关键词：doses prevention CONSERVED 
A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8^(+)T cell test
《Biosafety and Health》2024年第3期143-152,共10页Congling Qiu Bo Peng Chanchan Xiao Pengfei Chen Lipeng Mao Xiaolu Shi Zhen Zhang Ziquan Lv Qiuying Lv Xiaomin Zhang Jiaxin Li Yanhao Huang Qinghua Hu Guobing Chen Xuan Zou Xiaofeng Liang 
the Key Project of Shenzhen Science and Technology Innovation Commission(JCYJ20210324115411030);Natural Science Foundation of China(92169102);R&D Program of Guangzhou Laboratory(SRPG22-006);Sanming Project of Medicine in Shenzhen(SZSM202211023);GuangDong Basic and Applied Basic Research Foundation(2022B1515120043);the Open Project Fund of Guangdong Provincial People’s Hospital(YKY-KF202208);National Natural Science Foundation of China(81902097);Funding by Science and Technology Projects in Guangzhou(SL2023A04J01160);the Guangdong Basic and;Applied Basic Research Foundation(2023A1515140117);the fellowship of China Postdoctoral Science Foundation(2023TQ0136,2023M741379);supported by grants from the National Key Research and Development Plan(2023YFE0118700,2021YFC2301604);the Fundamental Research Funds for the Central Q4 Universities(21623406).
Since the outbreak of the coronavirus disease 2019(COVID-19)epidemic in 2019,the public health system has faced enormous challenges.Tracking the individuals who test positive for severe acute respiratory syndrome coro...
关键词：Asymptomatic coronavirus disease 2019 (COVID-19) EPITOPES Specific CD8^(+)T cell ELISPOT 
Antigen epitopes of animal coronaviruses:a mini-review
《Animal Diseases》2024年第1期19-26,共8页Mingjun Su Guanghui Zheng Xiangwen Xu Houhui Song 
supported by the Natural Science Foundation of Zhejiang Province(Q23C180006);the Zhejiang A&F University Talent Initiative Project(118-203402005901).
Coronaviruses are widespread in nature and can infect mammals and poultry,making them a public health concern.Globally,prevention and control of emerging and re-emerging animal coronaviruses is a great challenge.The m...
关键词：Animal coronavirus Antigen epitope B-cell epitope T-cell epitope Immune responses Vaccines 
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