IMMUNOINFORMATICS

作品数：14被引量：15H指数：2
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相关领域：医药卫生更多>>
相关作者：朱山风梁丽君黄平更多>>
相关机构：新疆维吾尔自治区人民医院广东省疾病预防控制中心中山大学新疆医科大学第一附属医院更多>>
相关期刊：《Food Quality and Safety》《Acta Biochimica et Biophysica Sinica》《Asian Pacific Journal of Tropical Medicine》《Infectious Disease Modelling》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches被引量：1
《Synthetic and Systems Biotechnology》2024年第4期667-683,共17页Caixia Tan Yuanyuan xiao Ting Liu Siyao Chen Juan Zhou Sisi Zhang Yiran Hu Anhua Wu Chunhui Li 
upported by the National Key Research and Development Program of China[No.2022YFC2009801,No.2022YFC2009805];the Natural Science Foundation of Hunan Province[No.2021JJ31071];the Project program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)[No.2021KFJJ05];Health Development Research Center of the National Health Commission,"Evidence-based Evaluation and Demonstration Base Construction Project of Infection Control Measures in Healthcare Institutions"[No.CNHDRC-KJ-L-2020-53-04375];Scientific and technological personnel lifting Project in Hunan Province[No.2023 TJ-Z11].
Clostridioides difficile(C.difficile),as the major pathogen of diarrhea in healthcare settings,has become increasingly prevalent within community populations,resulting in significant morbidity and mortality.However,th...
关键词：Clotridioides difficile(C.difficile) mRNA vaccine IMMUNOINFORMATICS Reverse vaccinology(RV) Molecular docking Molecular dynamics(MD)simulation 
Integrating immunoinformatics and computational epitope prediction for a vaccine candidate against respiratory syncytial virus
《Infectious Disease Modelling》2024年第3期763-774,共12页Truc Ly Nguyen Heebal Kim 
The authors are thankful to the Research Institute of Agriculture and Life Sciences,Seoul National University,and the BK21 FOUR Program of the Department of Agricultural Biotechnology,Seoul National University,Seoul,Republic of Korea,for supporting the research work;This research was supported by a fund(Project Code No.Z-1543082-2019-20-01)by Research of Animal and Plant Quarantine Agency,Republic of Korea.
Respiratory syncytial virus(RSV)poses a significant global health threat,especially affecting infants and the elderly.Addressing this,the present study proposes an innovative approach to vaccine design,utilizing immun...
关键词：Respiratory syncytial virus Multiepitope vaccine IMMUNOINFORMATICS Docking molecular Molecular dynamics simulation Immune simulation 
Recombinant vaccines:Current updates and future prospects
《Asian Pacific Journal of Tropical Medicine》2024年第8期338-350,共13页Vivek Kumar Anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar 
Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of illnesses.The technology improved vaccine manufacturing,rendering it more efficient and economical.These vaccines...
关键词：MALARIA DENGUE Emerging diseases IMMUNOINFORMATICS Virus-like particles CRISPR-Cas9 
Construction and efficacy testing of DNA vaccines containing HLA-A^(*)02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics
《Acta Biochimica et Biophysica Sinica》2024年第7期986-996,共11页Dan Tan Ning Kang Yuanfei Zhu Jia Hou Hanqing Wang Huijun Xu Cheng Zu Zixiang Gao Mu Liu Nannan Liu Qiang Deng Hongzhou Lu Jing Liu Youhua Xie 无 
supported by the grants from the Shanghai Municipal Science and Technology Major Project,the National Key R&D Program(No.2023YFC0872600);the National Natural Science Foundation of China(No.81971921).
Vaccines play essential roles in the fight against the COVID-19 pandemic.The development and assessment of COVID-19 vaccines have generally focused on the induction and boosting of neutralizing antibodies targeting th...
关键词：COVID-19 cellular immune response CD8^(+)T cell SARS-CoV-2 DNA vaccine 
Immunoinformatics assisted design of a multi-epitope kit for detecting Cronobacter sakazakii in powdered infant formula
《Food Quality and Safety》2024年第2期322-333,共12页Elijah K.Oladipo Olukayode I.Obisanya Victoria O.Owoeye Oyinlola G.Shittu Mautin G.Adamitonde Emmanuel C.Ikwuka Solomon O.Ojewale Adewale J.Tijani Feranmi A.Adedokun Amudatu A.Adedokun Temitope A.Oyedepo Helen Onyeaka 
Objectives:Cronobacter sakazakii,formerly Enterobacter sakazakii,is an emerging ubiquitous and opportunistic foodborne pathogen with a high mortality rate.It has been implicated in cases of meningitis,septicaemia,and ...
关键词：Powdered infant formula Cronobacter sakazakii BIOINFORMATICS IMMUNOINFORMATICS detection kit peptide-based EPITOPES analytical kits recombinant fusion protein PEPTIDES 
Decoding bovine coronavirus immune targets:an epitope informatics approach
《Animal Diseases》2024年第2期138-153,共16页Swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa Suresh Jayashree Anandakumar Nagendra Nath Barman Sheethal Manjunath Yamini Sri S Sharanagouda S.Patil 
Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle populations.This necessitates the development of efficacious vaccines...
关键词：IMMUNOINFORMATICS Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning 
Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection被引量：1
《Infectious Diseases & Immunity》2024年第1期10-24,共15页Cong Peng Fan Jiang Yinping Liu Yong Xue Peng Cheng Jie Wang Liang Wang Wenping Gong 
supported by the BeijingMunicipal Science&Technology Commission(7212103);the Eighth Medical Center of PLA General Hospital(MS202211002).
Background:Diagnosing latent tuberculosis(TB)infection(LTBI)and active TB(ATB)is crucial for preventing disease progression and transmission.However,current diagnostic tests have limitations in terms of accuracy and s...
关键词：TUBERCULOSIS Latent tuberculosis infection Active tuberculosis Multiepitope-based diagnostic biomarker Bioinformatics:Immunoinformatics 
Designing a multi-epitope vaccine against Peptostreptococcus anaerobius based on an immunoinformatics approach被引量：1
《Synthetic and Systems Biotechnology》2023年第4期757-770,共14页Yudan Mao Xianzun Xiao Jie Zhang Xiangyu Mou Wenjing Zhao 
supported by the National Key Research and Development Program of China(Grant No.2020YFA0907800);the National Natural Science Foundation of China(Grant No.32000096);the Shenzhen Science and Technology Innovation Program(KQTD20200820145822023);the Program of Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases(ZDSYS20220606100803007);the Foshan Science and Technology Innovation Program(2120001010795).
Peptostreptococcus anaerobius is an anaerobic bacterium,which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer(CRC)patients.Emerging evidence suggest P.anaerobius may contr...
关键词：Colorectal cancer Peptostreptococcus anaerobius PCWBR2 Immunoformatics MULTI-EPITOPE 
Reverse vaccinology assisted designing of multiepitope-based subunit vaccine against SARS-CoV-2被引量：5
《Infectious Diseases of Poverty》2020年第5期117-117,共1页Muhammad Tahir ul Qamar Farah Shahid Sadia Aslam Usman Ali Ashfaq Sidra Aslam Israr Fatima Muhammad Mazhar Fareed Ali Zohaib Ling-Ling Chen 
Background:Coronavirus disease 2019(COVID-19)linked with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)cause severe illness and life-threatening pneumonia in humans.The current COVID-19 pandemic demands a...
关键词：SARS-CoV-2 COVID-19 Structural protein EPITOPE Vaccine Multiepitope-based subunit vaccine IMMUNOINFORMATICS 
A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines被引量：1
《Journal of Cancer Metastasis and Treatment》2018年第1期10-33,共24页Taku A.Tokuyasu Jian-Dong Huang 
This work was supported by a National Basic Research Program of China(973 Program,No.2014CB745202);the Shenzhen Peacock Team Project(No.KQTD2015033117210153);the Shenzhen Science and Technology Innovation Committee Basic Science Research Grants(No.JCYJ20170413154523577,No.JCYJ20150629151046896);the Guangdong Natural Science Funds for Distinguished Young Scholar Grant(No.S2013050016987).
Cancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients.Adoptive cell transfer and checkpoint blockade therapies in particular both demons...
关键词：IMMUNOTHERAPY cancer vaccine IMMUNOINFORMATICS precision medicine combination therapy theoretical models systems biology 
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