MULTI-EPITOPE

作品数：15被引量：15H指数：2
导出分析报告
相关领域：医药卫生农业科学更多>>
相关作者：宋小凯更多>>
相关机构：江苏省农业科学院南京农业大学新疆维吾尔自治区人民医院新疆医科大学第一附属医院更多>>
相关期刊：《Science China(Life Sciences)》《Virologica Sinica》《Journal of Pharmaceutical Analysis》《Food Quality and Safety》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划江苏高校优势学科建设工程资助项目山东省自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Development of multi-epitope mRNA vaccine against Clostridioides difficile using reverse vaccinology and immunoinformatics approaches被引量：1
《Synthetic and Systems Biotechnology》2024年第4期667-683,共17页Caixia Tan Yuanyuan xiao Ting Liu Siyao Chen Juan Zhou Sisi Zhang Yiran Hu Anhua Wu Chunhui Li 
upported by the National Key Research and Development Program of China[No.2022YFC2009801,No.2022YFC2009805];the Natural Science Foundation of Hunan Province[No.2021JJ31071];the Project program of National Clinical Research Center for Geriatric Disorders(Xiangya Hospital)[No.2021KFJJ05];Health Development Research Center of the National Health Commission,"Evidence-based Evaluation and Demonstration Base Construction Project of Infection Control Measures in Healthcare Institutions"[No.CNHDRC-KJ-L-2020-53-04375];Scientific and technological personnel lifting Project in Hunan Province[No.2023 TJ-Z11].
Clostridioides difficile(C.difficile),as the major pathogen of diarrhea in healthcare settings,has become increasingly prevalent within community populations,resulting in significant morbidity and mortality.However,th...
关键词：Clotridioides difficile(C.difficile) mRNA vaccine IMMUNOINFORMATICS Reverse vaccinology(RV) Molecular docking Molecular dynamics(MD)simulation 
Leveraging computer-aided design and artificial intelligence to develop a next-generation multi-epitope tuberculosis vaccine candidate
《Infectious Medicine》2024年第4期53-73,共21页Li Zhuang Awais Ali Ling Yang Zhaoyang Ye Linsheng Li Ruizi Ni Yajing An Syed Luqman Ali Wenping Gong 
sponsored by the Beijing Nova Program(20240484526).
Background:Tuberculosis(TB)remains a global public health challenge.The existing Bacillus Calmette–Guérin vaccine has limited efficacy in preventing adult pulmonary TB,necessitating the development of new vaccines w...
关键词：TUBERCULOSIS Multi-epitope vaccine Computer-aided design Artificial intelligence IMMUNOGENICITY 
Comparative study of trastuzumab modification analysis using mono/ multi-epitope affinity technology with LC-QTOF-MS
《Journal of Pharmaceutical Analysis》2024年第11期1675-1685,共11页Chengyi Zuo Jingwei Zhou Sumin Bian Qing Zhang Yutian Lei Yuan Shen Zhiwei Chen Peijun Ye Leying Shi Mao Mu Jia-Huan Qu Zhengjin Jiang Qiqin Wang 
supported by the National Natural Science Foundation of China(Grant Nos.:82373829,82273893,and 82173773);the Natural Science Foundation of Guangdong Province,China(Grant Nos.:2021A1515220099,and 2022A1515011576);the High-End Foreign Experts Project,China(Grant No.:G2021199005L);the Science and Technology Program of Guangdong Provincial Medical Products Administration,China(Grant Nos.:2023TDZ11,and 2022ZDB04).
Dynamic tracking analysis of monoclonal antibodies(mAbs)biotransformation in vivo is crucial,as certain modifications could inactivate the protein and reduce drug efficacy.However,a particular challenge(i.e.immune rec...
关键词：Monoclonal antibody Multi-epitope affinity technology Biotransformation analysis LC-QTOF-MS Breast cancer 
Immunoinformatics assisted design of a multi-epitope kit for detecting Cronobacter sakazakii in powdered infant formula
《Food Quality and Safety》2024年第2期322-333,共12页Elijah K.Oladipo Olukayode I.Obisanya Victoria O.Owoeye Oyinlola G.Shittu Mautin G.Adamitonde Emmanuel C.Ikwuka Solomon O.Ojewale Adewale J.Tijani Feranmi A.Adedokun Amudatu A.Adedokun Temitope A.Oyedepo Helen Onyeaka 
Objectives:Cronobacter sakazakii,formerly Enterobacter sakazakii,is an emerging ubiquitous and opportunistic foodborne pathogen with a high mortality rate.It has been implicated in cases of meningitis,septicaemia,and ...
关键词：Powdered infant formula Cronobacter sakazakii BIOINFORMATICS IMMUNOINFORMATICS detection kit peptide-based EPITOPES analytical kits recombinant fusion protein PEPTIDES 
Designing a multi-epitope vaccine against Peptostreptococcus anaerobius based on an immunoinformatics approach被引量：1
《Synthetic and Systems Biotechnology》2023年第4期757-770,共14页Yudan Mao Xianzun Xiao Jie Zhang Xiangyu Mou Wenjing Zhao 
supported by the National Key Research and Development Program of China(Grant No.2020YFA0907800);the National Natural Science Foundation of China(Grant No.32000096);the Shenzhen Science and Technology Innovation Program(KQTD20200820145822023);the Program of Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases(ZDSYS20220606100803007);the Foshan Science and Technology Innovation Program(2120001010795).
Peptostreptococcus anaerobius is an anaerobic bacterium,which has been found selectively en-riched in the fecal and mucosal microbiota of colorectal cancer(CRC)patients.Emerging evidence suggest P.anaerobius may contr...
关键词：Colorectal cancer Peptostreptococcus anaerobius PCWBR2 Immunoformatics MULTI-EPITOPE 
A biepitope,adjuvant-free,self-assembled influenza nanovaccine provides cross-protection against H3N2 and H1N1 viruses in mice被引量：1
《Nano Research》2022年第9期8304-8314,共11页Yongbo Qiao YaXin Zhang Jie Chen Shenghui Jin Yarning Shan 
the National Natural Science Foundation of China(No.31770996).
Currently,the incorporation of multiple epitopes into vaccines is more desirable than the incorporation of a single antigen for universal influenza vaccine development.However,epitopes induce poor immune responses.Alt...
关键词：INFLUENZA universal vaccine MULTI-EPITOPE NANOVACCINE 
Inducible Expression on Multi-epitope of Porcine Circovirus Type 2 and Its Immunological Competence
《Animal Husbandry and Feed Science》2016年第3期151-154,158,共5页Dong Lin Wang Yanping Wang Jinliang Mo Ling Shen Zhiqiang Liu Zengshan 
Supported by Shandong Province Natural Science Foundation of China(ZR2013CQ006)
In order to obtain induction expressed porcine circovirus type 2（PCV2）multi-epitope with good immunogenicity in vitro.Major epitopes of PCV2 were screened in the test,epitopes were composed sequentially,the c DNA se...
关键词：Porcine circovirus type 2 Multi-epitope Induced expression Immunogenicity 
Immunogenicity of multi-epitope-based vaccine candidates administered with the adjuvant Gp96 against rabies被引量：1
《Virologica Sinica》2016年第2期168-175,共8页Yange Niu Ye Liu Limin Yang Hongren Qu Jingyi Zhao Rongliang Hu Jing Li Wenjun Liu 
supported by grants from the Special Fund for Agro-scientific Research in the Public Interest(201103032);the Fund of State Key Laboratory of Veterinary Biotechnology(SKLVBF201614);the National High Technology Research and Development Program of China(2015BAD11B02);Key Research Program of the Chinese Academy of Sciences(KSZD-EW-Z-005-001);the Special Fund for Chinese Academy of Sciences(CZBZX-1);WJL is the principal investigator of the NSFC Innovative Research Group(Grant No.81321063)
Rabies, a zoonotic disease, causes > 55,000 human deaths globally and results in at least 500 million dollars in losses every year. The currently available rabies vaccines are mainly inactivated and attenuated vaccine...
关键词：rabies virus multi-epitope-based vaccine immunogenicity evaluation GP96 
Multi-epitope chimeric antigen used as a serological marker to estimate Plasmodium falciparum transmission intensity in the border area of China-Myanmar被引量：2
《Infectious Diseases of Poverty》2016年第1期898-908,共11页Mei-Xue Yao Xiao-Dong Sun Yu-Hui Gao Zhi-Bin Cheng Wei-Wei Deng Jia-Jia Zhang Heng Wang 
supported in full by the National Special Science and Technology Project for Major Infectious Diseases of China(No.2012ZX10004220).
Background:Following the decline of malaria transmission in many countries and regions,serological parameters have become particularly useful for estimating malaria transmission in low-intensity areas.This study evalu...
关键词：Plasmodium falciparum SEROLOGY Multi-epitope chimeric antigens Transmission intensity ChinaMyanmar border 
A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice被引量：1
《Acta Biochimica et Biophysica Sinica》2014年第5期401-408,共8页Jianxin Tu B ailong Hou Bingbing Wang Xiaoyun Lin Wenci Gong Haiyan Dong Shanli Zhu Shao Chen Xiangyang Xue Kong-Nan Zhao Lifang Zhang 
This work was supported in part by the grants from the National Natural Science Foundation of China （30972669）, the Zhejiang Provincial Natural Science Foundation of China （Y2100611）, and the Wenzhou Science and Technology Bureau （Y20100014, and Y20100090）.
We evaluated the immunogenicity and efficacy of a candidate vaccine comprising the major outer membrane protein （MOMP） multi-epitope of Chlamydia trachomatis. A short gene of muiti-epitope derived from MOMP containi...
关键词：Chlamydia trachomatis VACCINE major outermembrane protein MULTI-EPITOPE humoral immuneresponse cytotoxic T lymphocyte （CTL） response 
全选清除导出
共2页<12>
检索报告 对象比较 聚类工具 使用帮助 返回顶部