Recombinant vaccines:Current updates and future prospects  

作　　者：Vivek Kumar Anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar 

机构地区：[1]Department of Allied Medical Sciences,School of Allied Medical Sciences,Lovely Professional University,Phagwara,Punjab,India [2]Bioengineering,Division of Department of Bioscience and Biomedical Engineering,Indian Institute of Technology Bhilai,Chhattisgarh,India [3]Department of Biotechnology,IMS Engineering College,Ghaziabad,U.P.,India [4]Department of Chemistry and Biochemistry,University of Windsor,Ontario N9B3P4,Canada [5]Biological and Biocomputational Laboratory,Department of Life Sciences,Sharda School of Basic Sciences and Research,Sharda University,Greater Noida,U.P.,India [6]Department of System Biology,Columbia University Irving Medical Center,New York,NY 10032,USA [7]Department of Life Sciences,Sharda School of Basic Sciences and Research,Sharda University,Greater Noida,U.P.,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2024年第8期338-350,共13页亚太热带医药杂志（英文版）

摘　　要：Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of illnesses.The technology improved vaccine manufacturing,rendering it more efficient and economical.These vaccines have multiple advantages compared to conventional vaccines.The pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing globally.This work offers an overview of the prospects and advantages associated with recombinant vaccines.Additionally,it discusses some of the challenges likely to arise in the future.Their ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines.Moreover,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many prospects.This review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关 键 词：MALARIA DENGUE Emerging diseases IMMUNOINFORMATICS Virus-like particles CRISPR-Cas9 

分 类 号：R186[医药卫生—流行病学]