NANOBODY

作品数：51被引量：66H指数：4
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相关领域：医药卫生更多>>
相关作者：张永学王天文王平马兴元张娜更多>>
相关机构：华中科技大学华中科技大学同济医学院附属协和医院华东理工大学上海交通大学更多>>
相关期刊：《Open Journal of Biophysics》《Asian Pacific Journal of Tropical Biomedicine》《Journal of Oceanology and Limnology》《Food Science and Human Wellness》更多>>
相关基金：国家自然科学基金上海市自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy
《Acta Pharmaceutica Sinica B》2024年第11期4806-4818,共13页Xiaozhi Xi Yanqing Wang Guiqi An Shitao Feng Qiumei Zhu Zhongqiu Wu Jin Chen Zhicheng Zuo Qiang Wang Ming-Wei Wang Yuchao Gu 
Qingdao Marine Science and Technology Center(No.2022QNLM030003-4 and 8-01,China);Program of National Natural Science Foundation of China(No.82273846);Taishan Scholars Program(No.tsqn202211058,China).
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 has emerged as a promising target for antibody-drug conjugates (...
关键词：Shark VNAR IMMUNOTOXINS TROP-2Epitope identification ANTI-TUMOR Pseudomonas exotoxin A NANOBODY Breast cancer 
Optical fiber biosensor with a bilayer bio-sensitive film for label-free detection of pseudomonas exotoxin A
《Chinese Optics Letters》2024年第11期36-41,共6页Wanmei Guo Yongsen Yu Chao Xin Guangyong Jin 
supported by the National Natural Science Foundation of China (Nos.91860140,62090064,and U19A2077)。
A biosensor featuring an S-tapered fiber(STF) with a composite bio-sensitive film comprising graphene oxide and gold nanoparticles, has been proposed for the rapid, highly sensitive, and label-free detection of pseudo...
关键词：optical fiber biosensor composite film nanobody:pseudomonas exotoxin. 
Single-domain antibodies as therapeutics for solid tumor treatment
《Acta Pharmaceutica Sinica B》2024年第7期2854-2868,共15页Mingkai Wang Tianlei Ying Yanling Wu 
supported by grants from the National Key R&D Program of China(2019YFA0904400);National Natural Science Foundation of China(32270984);Science and Technology Commission of Shanghai Municipality(23XD1400800,China);Shanghai Municipal Health Commission(GWVI-11.2-YQ46,China).
Single-domain antibodies(sdAbs),initially identified in camelids or sharks and commonly referred to as nanobodies or VNARs,have emerged as a promising alternative to conventional therapeutic antibodies.These sdAbs hav...
关键词：Single-domain antibody NANOBODY HUMANIZATION Fully human singledomain antibody Solid tumor 
Two nanobody‑based immunoassays to differentiate antibodies against genotype 1 and 2 porcine reproductive and respiratory syndrome virus
《Animal Diseases》2024年第2期98-114,共17页Xu Chen Yueting Chang Lu Zhang Xinyu Zhao Zhihan Li Zhijie Zhang Pinpin Ji Qingyuan Liu Jiakai Zhao Jiahong Zhu Baoyuan Liu Xinjie Wang Yani Sun Qin Zhao 
funded by grants from the National Key R&D Program of China(2023YFD1800304);the National Natural Science Foundation of China to QZ(32273041);the Natural Science Foundation of Shaanxi Province of China(2022JC-12);the Central Public-interest Scientific Institution Basal Research Fund,National Data Center of Animal Health.
Porcine reproductive and respiratory syndrome virus(PRRSV)infection causes significant economic loss to the global pig industry.Genotype 1 and 2 PRRSV(PRRSV-1 and-2)infections have been reported in China,Europe and Am...
关键词：PRRSV Competitive ELISA NANOBODY Antigen epitope 
Nanobody-based food allergen surveillance:current status and prospects
《Food Quality and Safety》2024年第2期227-238,共12页Yi Wang Sihao Wu Ang Li Huan Lv Xuemeng Ji Yaozhong Hu Shuo Wang 
funded by the National Natural Science Foundation of China(No.32272403);the National Key Research and Development Program of China(No.2022YFF1102400).
The incidence of food allergy has increased in recent decades,posing drastic risks to sensitive individuals,leading to mild to severe allergic symptoms.There is still no effective immune therapeutic strategy for food ...
关键词：Food allergy food allergen NANOBODY IMMUNOASSAY 
Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain
《Signal Transduction and Targeted Therapy》2024年第6期2726-2737,共12页Bo Liu Honghui Liu Pu Han Xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang 
supported by the National Key R&D Program of China(2022YFC2303403);the National Science Fund for Distinguished Young Scholars(82225021);supported by the Young Scientists in Basic Research(YSBR-010).
Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging...
关键词：doses prevention CONSERVED 
Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies
《Virologica Sinica》2024年第3期478-489,共12页Jiahong Zhu Qingyuan Liu Liuya Li Runyu Zhang Yueting Chang Jiakai Zhao Siyu Liu Xinyu Zhao Xu Chen Yani Sun Qin Zhao 
supported by the Natural Science Foundation of China(grant no.32273041);the Natural Science Foundation of Shaanxi Province of China(grant no.2022JC-12);the Key R&D Program of Shaanxi Province(grant no.S2022-YF-YBNY-0673);the Central Public-interest Scientific Institution Basal Research Fund.
African swine fever virus(ASFV)poses a significant threat to the global swine industry.Currently,there are no effective vaccines or treatments available to combat ASFV infection in pigs.The primary means of controllin...
关键词：African swine fever virus(ASFV) ASFV-p72 ASFV-CD2v Nanobody-HRP Competitive ELISA 
A nanobody-based blocking enzyme-linked immunosorbent assay for detecting antibodies against pseudorabies virus glycoprotein E
《Journal of Integrative Agriculture》2024年第4期1354-1368,共15页Huanhuan Lü Pinpin Ji Siyu Liu Ziwei Zhang Lei Wang Yani Sun Baoyuan Liu Lizhen Wang Qin Zhao 
supported by the National Natural Science Foundation of China(32273041);the Key R&D Program of Shaanxi Province,China(2022NY-104);the Natural Science Foundation of Shaanxi Province,China(2022JC-12)。
Pseudorabies(PR)is an acute infectious disease of pigs caused by the PR virus(PRV)and results in great economic losses to the pig industry worldwide.PRV glycoprotein E(gE)-based enzyme-linked immunosorbent assay(ELISA...
关键词：NANOBODY nanobody-HRP blocking ELISA PRV-gE ANTIBODY 
EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment被引量：1
《Nano Research》2024年第2期848-857,共10页Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan Zhu Xinyuan Zhu Chuan Zhang 
supported by the National Key Research and Development Program of China(No.2018YFA0902601);the National Natural Science Foundation of China(Nos.52225302,52103265,and 22175116);the Shanghai Sailing Program(No.21YF1434300);the Natural Science Foundation of Shanghai(No.23ZR1448000);the Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400219).
Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or multidrug-resistanc...
关键词：antisense oligonucleotide chemogene NANOBODY drug delivery system pancreatic cancer 
Generation and characterization of nanobodies targeting GPCR
《Biophysics Reports》2024年第1期22-30,共9页Shenglan Zhang Zhiran Fan Jianfeng Liu 
financially supported by the Key Technologies R&D Program of Guangdong Province(2010A080813001);GuangZhou Basic and Applied Basic Research Foundation(SL2022A04J00399).
G protein-coupled receptors(GPCRs)are a large family of cell membrane proteins that are important targets for drug discovery.Nanobodies,also known as VHH(variable domains of heavy chain-only anti-bodies,HcAbs)antibodi...
关键词：NANOBODY Single domain antibody Heavy chain-only antibody GPCR G protein-coupled receptor 
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