云南高校图书馆联盟文献共享服务平台- GPCR

GPCR: 作品数：195被引量：316H指数：8; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：蒲雪梅白波吕强李梦龙陈京更多>>; 相关机构：中国科学院山东大学中国科学院大学华东师范大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划山东省自然科学基金国家高技术研究发展计划更多>>

Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling: 《Acta Pharmacologica Sinica》2025年第4期795-804,共10页Zheng-Jie Chia Hirushi Kumarapperuma Ruizhi Zhang Peter J.Little Danielle Kamato; supported by a Future Leader Fellowship(106605)from the National Heart Foundation of Australia;HK and ZJC are supported by the Research Training Scholarship from the University of Queensland.; The Smad transcription factors are well known for their role at the core of transforming growth factor-β(TGF-β)signalling.However,recent evidence shows that the Smad transcription factors play a vital role downstrea...; 关键词：transforming growth factor-beta receptor SMAD transactivation dependent GPCR signalling Akt phospho-Smad

藏绵羊瘤胃上皮ceRNA介导GPCR-cAMP-PKA信号通路调控SCFAs: 《西北农业学报》2025年第4期581-591,共11页沙玉柱刘秀赵生国邵鹏阳王翻兄杨文鑫陈小伟谢转回; 国家自然科学基金(32260820);甘肃农业大学科技创新基金(GAU-QDFC-2022-06);甘肃海智计划示范项目(GSHZSF2023-01);甘肃农业大学学科团队项目(GAU-XKTD-2022-21)。; 旨在探究藏绵羊瘤胃上皮对短链脂肪酸(SCFAs)的吸收转运分子机制。选择1周岁(±1月龄)健康的放牧藏绵羊母羊12只,分别对其暖季(8月份)和冷季(12月份)的瘤胃上皮组织进行全转录组(RNAseq)测序,筛选差异ceRNA调控网络,检测cAMP-PKA信号通...; 关键词：冷季藏绵羊 SCFAs 瘤胃上皮 ceRNA cAMP

AlphaFold3 versus experimental structures:assessment of the accuracy in ligand-bound G protein-coupled receptors: 《Acta Pharmacologica Sinica》2025年第4期1111-1122,共12页Xin-heng He Jun-rui Li Shi-yi Shen H.Eric Xu; supported by the National Key R&D Program of China(2022YFC2703105 to HEX);The National Natural Science Foundation of China(32130022,82121005);CAS Strategic Priority Research Program(XDB37030103 to HEX);Shanghai Municipal Science and Technology Major Project(2019SHZDZX02 to HEX);Shanghai Municipal Science and Technology Major Project(HEX);the Lingang Laboratory,Grant No.LG-GG-202204-01(HEX).; G protein-coupled receptors(GPCRs)are critical drug targets involved in numerous physiological processes,yet many of their structures remain unresolved due to inherent flexibility and diverse ligand interactions.This ...; 关键词：AlphaFold structure-based drug design artificial intelligence GPCR structural biology

Astrocytic G Protein-Coupled Receptors in Drug Addiction: 《Engineering》2025年第1期256-265,共10页Alexander K.Zinsmaier Eric J.Nestler Yan Dong; partially supported by the National Institutes of Health(NIH)grants DA056213(to Alexander K.Zinsmaier),DA053388(to Eric J.Nestler),DA023206(to Yan Dong),DA060868(to Yan Dong),and DA040620(to Eric J.Nestler and Yan Dong)。; Understanding the cellular mechanisms of drug addiction remains a key task in current brain research.While neuron-based mechanisms have been extensively explored over the past three decades,recent evidence indicates a...; 关键词：ASTROCYTE GPCR Nucleus accumbens ADDICTION MGLUR5 DOPAMINE

The landscape of GPCR in the skin epidermal stem cells: From thebasic to the clinical: 《生理学报》2024年第6期881-892,共12页ZHANG Zhi-Lin MA Xiao-Qing ZHANG Zhao-Tian ZHANG Rong-Hao CUI Ru-Tao; supported by the National Natural Science Foundation of China(No.U21A20379);National Key Research and Development Program of China(No.2021YFA1101000,2021YFA1101004);Research Fund for Foreign Scholars of China(No.82250710176);Leading Innovation and Entrepreneurship Team of Hangzhou(No.TD2020006).; Skin, as the body's largest organ, acts as the primary defense mechanism against infection and injury. The maintenance ofskin health heavily relies on the regulation of epidermal stem cells, crucial for ensuring epide...; 关键词：G protein-coupled receptor SKIN epidermal stem cells

Beyond the classic GPCR:unraveling the role of GPR155 in cholesterol sensing and signaling: 《Signal Transduction and Targeted Therapy》2024年第12期5361-5363,共3页Torsten Schöneberg; supported by the German Research Foundation(DFG)in CRC1052(project number 209933838);CRC1423(project number 421152132).; In a recent cryo-EM study published in Nature,Bayly-Jones and coworkers have provided detailed molecular insights into the dimerization and cholesterol binding of the orphan G proteincoupled receptor GPR155,its potent...; 关键词：INTEGRATE INSIGHT DIMER

基于体外生物活性的中国地表水中G蛋白偶联受体药物筛选: 《大连理工大学学报》2024年第6期573-580,共8页郑有成张晗; 国家自然科学基金资助项目(22106018);中央高校基本科研业务费专项资金资助项目(DUT20RC(3)080).; 低浓度(ng/L至μg/L)的药物在环境水体中被广泛检出,其对水生生物存在潜在的生态风险,进而受到人们的关注.G蛋白偶联受体(GPCR)是一类在人体与动物体内高度保守的跨膜蛋白,约40%市售药物作用于GPCR.然而,GPCR药物在中国水环境中赋存情...; 关键词：G蛋白偶联受体(GPCR) G蛋白偶联受体药物生物活性生态风险筛选

中国三株牛结节性皮肤病病毒的分离鉴定及其GPCR基因分析: 《畜牧兽医学报》2024年第12期5620-5630,共11页周祉玉杜吉革莘若兰张嘉雯潘晨帆印春生陈小云朱真; “十四五”国家重点研究计划项目课题(2023YFD1802501)。; 为了解我国牛结节性皮肤病(lumpy skin disease,LSD)田间毒株流行情况及遗传进化情况并观察其生物学特征,本研究对临床疑似发生牛结节性皮肤病的牛皮肤结节样本进行PCR检测、病毒分离、免疫荧光鉴定、电镜观察、GPCR基因测序和遗传进化...; 关键词：牛结节性皮肤病病毒分离鉴定生物学特征遗传进化分析

GPCR二聚体结构及功能: 《生物化学与生物物理进展》2024年第11期2787-2804,共18页李传宝黎晨卉薛礼; 国家自然科学基金(82172605)资助项目。; G蛋白偶联受体(G-protein coupled receptor,GPCR)是最广泛表达的膜蛋白家族之一,其可接收胞外信号刺激,通过自身构象变化激活胞内G蛋白等一系列信号通路,参与众多生理调节过程,具有重要的功能,因此其也是重要的药物靶点。GPCR二聚化是...; 关键词：G蛋白偶联受体二聚体 GPCR二聚体结构 GPCR二聚体功能

Genome-wide pan-GPCR cell libraries accelerate drug discovery: 《Acta Pharmaceutica Sinica B》2024年第10期4296-4311,共16页Hanting Yang Yongfu Wang Wei Liu Taiping He Jiayu Liao Zhongzhi Qian Jinghao Zhao Zhaotong Cong Dan Sun Zhixiang Liu Can Wang Lingping Zhu Shilin Chen; supported by introducing the talented person scientific research starts funds subsidization project of Chengdu University of Traditional Chinese Medicine(030040019,030040017,China).; G protein-coupled receptors(GPCRs)are pivotal in mediating diverse physiological and pathological processes,rendering them promising targets for drug discovery.GPCRs account for about 40%of FDA-approved drugs,represen...; 关键词：G-protein coupled receptors Genome-wide pan-GPCR Transgenic cell library High-throughput screening Drug discovery

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

GPCR

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

GPCR

检索结果分析

下载全文

用户登录

高级检索检索式检索