Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling  

作　　者：Zheng-Jie Chia Hirushi Kumarapperuma Ruizhi Zhang Peter J.Little Danielle Kamato 

机构地区：[1]Institute for Biomedicine and Glycomics,Griffith University,Nathan,QLD,Australia [2]School of Pharmacy,The University of Queensland,Woolloongabba,QLD,Australia [3]School of Environment and Science,Griffith Sciences,Griffith University,Nathan,QLD,Australia [4]Department of Pharmacy,Guangzhou Xinhua University,Guangzhou 510520,China

出　　处：《Acta Pharmacologica Sinica》2025年第4期795-804,共10页中国药理学报(英文版)

基　　金：supported by a Future Leader Fellowship(106605)from the National Heart Foundation of Australia;HK and ZJC are supported by the Research Training Scholarship from the University of Queensland.

摘　　要：The Smad transcription factors are well known for their role at the core of transforming growth factor-β(TGF-β)signalling.However,recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors including G protein-coupled receptors(GPCR).The versatility of Smad transcription factors originated from the two regions that can be differently activated by the TGF-β receptor superfamily or through the recruitment of intracellular kinases stimulated by other receptors classes such as GPCRs.The classic GPCR signalling cascade is further expanded to conditional adoption of the Smad transcription factor under the stimulation of Akt,demonstrating the unique involvement of the Smad transcription factor in GPCR signalling pathways in disease environments.In this review,we provide a summary of the signalling pathways of the Smad transcription factors as an important downstream mediator of GPCRs,presenting exciting opportunities for discovering new therapeutic targets for diseases.

关 键 词：transforming growth factor-beta receptor SMAD transactivation dependent GPCR signalling Akt phospho-Smad 

分 类 号：R363[医药卫生—病理学]