Astrocytic G Protein-Coupled Receptors in Drug Addiction  

作　　者：Alexander K.Zinsmaier Eric J.Nestler Yan Dong 

机构地区：[1]Department of Neuroscience,University of Pittsburgh,Pittsburgh,PA 15260,USA [2]Nash Family Department of Neuroscience and Friedman Brain Institute,Icahn School of Medicine at Mount Sinai,New York City,NY 10029,USA

出　　处：《Engineering》2025年第1期256-265,共10页工程(英文)

基　　金：partially supported by the National Institutes of Health(NIH)grants DA056213(to Alexander K.Zinsmaier),DA053388(to Eric J.Nestler),DA023206(to Yan Dong),DA060868(to Yan Dong),and DA040620(to Eric J.Nestler and Yan Dong)。

摘　　要：Understanding the cellular mechanisms of drug addiction remains a key task in current brain research.While neuron-based mechanisms have been extensively explored over the past three decades,recent evidence indicates a critical involvement of astrocytes,the main type of non-neuronal cells in the brain.In response to extracellular stimuli,astrocytes modulate the activity of neurons,synaptic transmission,and neural network properties,collectively influencing brain function.G protein-coupled receptors(GPCRs)expressed on astrocyte surfaces respond to neuron-and environment-derived ligands by activating or inhibiting astrocytic signaling,which in turn regulates adjacent neurons and their circuitry.In this review,we focus on the dopamine D1 receptors(D1R)and metabotropic glutamate receptor 5(mGLUR5 or GRM5)—two GPCRs that have been critically implicated in the acquisition and maintenance of addiction-related behaviors.Positioned as an introductory-level review,this article briefly discusses astrocyte biology,outlines earlier discoveries about the role of astrocytes in substance-use disorders(SUDs),and provides detailed discussion about astrocytic D1Rs and mGLUR5s in regulating synapse and network functions in the nucleus accumbens(NAc)—a brain region that mediates addictionrelated emotional and motivational responses.This review serves as a stepping stone for readers of Engineering to explore links between astrocytic GPCRs and drug addiction and other psychiatric disorders.

关 键 词：ASTROCYTE GPCR Nucleus accumbens ADDICTION MGLUR5 DOPAMINE 

分 类 号：R749.6[医药卫生—神经病学与精神病学]