IMMUNOTOXINS

作品数：6被引量：3H指数：1
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相关期刊：《Cellular & Molecular Immunology》《Chinese Medical Journal》《Chinese Journal of Cancer Research》《Acta Pharmaceutica Sinica B》更多>>
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A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy
《Acta Pharmaceutica Sinica B》2024年第11期4806-4818,共13页Xiaozhi Xi Yanqing Wang Guiqi An Shitao Feng Qiumei Zhu Zhongqiu Wu Jin Chen Zhicheng Zuo Qiang Wang Ming-Wei Wang Yuchao Gu 
Qingdao Marine Science and Technology Center(No.2022QNLM030003-4 and 8-01,China);Program of National Natural Science Foundation of China(No.82273846);Taishan Scholars Program(No.tsqn202211058,China).
TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 has emerged as a promising target for antibody-drug conjugates (...
关键词：Shark VNAR IMMUNOTOXINS TROP-2Epitope identification ANTI-TUMOR Pseudomonas exotoxin A NANOBODY Breast cancer 
Immunotoxin Therapy for Lung Cancer
《Chinese Medical Journal》2017年第5期607-612,共6页Li-Yi Xie Hai-Lan Piao Min Fan Zhen Zhang Chen Wang Darell D Bigner Xu-Hui Bao 
The work was supported by grants from the Young Scientists Fund from the National Natural Science Foundation of China （No. 81401896）, and the Pujiang Talent Program from Shanghai Municipal Human Resource Bureau and Shanghai Science and Technology Committee （No. 14PJ1402000）.
INTRODUCTIONLung cancer is the leading cause for cancer-related deaths in both genders throughout the world. In the United States alone, there were 224,390 estimated new lung cancer cases and 158,080 estimated deaths ...
关键词：IMMUNOTHERAPY IMMUNOTOXINS Lung Neoplasms Molecular Targeted Therapy 
Immunotoxins and Cancer Therapy被引量：2
《Cellular & Molecular Immunology》2005年第2期106-112,共7页ZhengLi TaoYu PingZhao JieMa 
In the past decade,an increased amount of clinicallyloriented research involving immunotoxins has been published. Immunotoxins are a group of artificially-made cytotoxic molecules targeting cancer cells.These molecule...
关键词：IMMUNOTOXIN cancer therapy Pseudomonas exotoxin SCFV 
Induction of islet transplantation tolerance with anti-CD_4, anti-CD_8 immunotoxins and donor soluble antigen被引量：1
《Chinese Medical Journal》1999年第12期53-55,共3页兰平 严律南 肖路加 
ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina!(No39700145)
Objective To induce islet grafting tolerance by intravenous injection of anti CD 4, anti CD 8 immunotoxins and donor soluble antigen Methods Fourteen days or 7 days prior to transplantation, the immunotoxin of...
关键词：immunotoxin  · donor soluble antigen  · islet transplantation  · immunotolerance 
POTENT DEGLYCOSYLATED RICIN A CHAIN IMMUNOTOXINS SPECIFICALLY KILLING OF XENOTROPIC MURINE RETROVIRUS-INFECTED CELLS
《Chinese Medical Journal》1994年第5期65-67,共3页吴敏 MasaakiMiyazawa MasatoNose MasashisaKyogoku 
Immunotoxins (ITs) are conjugates between toxin and specific ligands, such as monoclonal antibodies (McAb) and growth factor, which may result in potent and specific killing of antigen positive cells. This approach wa...
STUDY OF ANTI-CD9 AND CD 10 IMMUNOTOXINS KILLING LEUKEMIC CELLS AND THE EFFECT ON HEMATOPOIESIS
《Chinese Journal of Cancer Research》1991年第4期16-20,共5页黎燕 贺永怀 陈兴 孙英勋 沈倍奋 
Immuntoxins were synthesized by conjugating a plant toxic ricin with to three different monclonal antibodiesMoAb) directed against markers of human pre- B lymphocyte leukemic cells. It is useful to eliminate residual ...
关键词：immunotoxin. leukemia. 
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