云南高校图书馆联盟文献共享服务平台- IMMUNOTOXIN

IMMUNOTOXIN: 作品数：18被引量：22H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：许蔓春沈倍奋黎燕吕善根更多>>; 相关机构：广州军区广州总医院中国人民解放军总医院军事医学科学院更多>>; 相关期刊：《Chinese Medical Journal》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《World Journal of Gastroenterology》更多>>; 相关基金：国家高技术研究发展计划国家自然科学基金更多>>

A novel shark VNAR antibody-based immunotoxin targeting TROP-2 for cancer therapy: 《Acta Pharmaceutica Sinica B》2024年第11期4806-4818,共13页Xiaozhi Xi Yanqing Wang Guiqi An Shitao Feng Qiumei Zhu Zhongqiu Wu Jin Chen Zhicheng Zuo Qiang Wang Ming-Wei Wang Yuchao Gu; Qingdao Marine Science and Technology Center(No.2022QNLM030003-4 and 8-01,China);Program of National Natural Science Foundation of China(No.82273846);Taishan Scholars Program(No.tsqn202211058,China).; TROP-2, a tumor-associated antigen, has been implicated in the progression of various epithelial tumors. Due to its favorable expression profile, TROP-2 has emerged as a promising target for antibody-drug conjugates (...; 关键词：Shark VNAR IMMUNOTOXINS TROP-2Epitope identification ANTI-TUMOR Pseudomonas exotoxin A NANOBODY Breast cancer

Immunotoxin Therapy for Lung Cancer: 《Chinese Medical Journal》2017年第5期607-612,共6页Li-Yi Xie Hai-Lan Piao Min Fan Zhen Zhang Chen Wang Darell D Bigner Xu-Hui Bao; The work was supported by grants from the Young Scientists Fund from the National Natural Science Foundation of China （No. 81401896）, and the Pujiang Talent Program from Shanghai Municipal Human Resource Bureau and Shanghai Science and Technology Committee （No. 14PJ1402000）.; INTRODUCTIONLung cancer is the leading cause for cancer-related deaths in both genders throughout the world. In the United States alone, there were 224,390 estimated new lung cancer cases and 158,080 estimated deaths ...; 关键词：IMMUNOTHERAPY IMMUNOTOXINS Lung Neoplasms Molecular Targeted Therapy

Epidermal growth factor receptor is overexpressed in neuroblastoma tissues and cells: 《Acta Biochimica et Biophysica Sinica》2016年第8期762-767,共6页Chao Zheng Ruling Shen Kai Li Na Zheng Yuqing Zong Danrong Ye Qingcheng Wang Zuopeng Wang Lian Chen Yangyang Ma; Neuroblastoma is the most common abdominal malignant tumor in childhood. Immunotoxin （IT） that targets the tumor cell surface receptor is a new supplementary therapeutic treatment approach. The purpose of this study...; 关键词：NEUROBLASTOMA IMMUNOTOXIN epidermal growth factor receptor

The efficacy of NP11-4-derived immunotoxin scFv-artesunate in reducing hepatic fibrosis inducedby Schistosoma japonicum in mice被引量：5: 《The Journal of Biomedical Research》2011年第2期148-154,共7页Hong Li Chunyan Gu Yongya Ren Yang Dai Xiaojuan Zhu Jing Xu Yuhua Li Zhenning Qiu Jin Zhu Yinchang Zhu Xiaohong Guan Zhenqing Feng; supported by a grant from the National High Technology Research and Development Program of China ("863"ProgramNo.2006AA02Z415); Schistosomiasis is one of the most prevalent parasitic diseases in China, and hepatic fibrosis caused by schistosome infection is the principal cause of death. The aim of this study was to evaluate the efficacy of NPl...; 关键词：Schistosoma japonicum SCFV IMMUNOTOXIN hepatic fibrosis

Application of anti-CD103 immunotoxin for saving islet allograft in context of transplantation被引量：4: 《Chinese Medical Journal》2010年第24期3644-3651,共8页ZHANG Lei Gregg A. Hadley; Background Previous studies using knockout mice document a key role for the integrin CD103 in promoting organ allograft rejection and graft-versus-host disease. However, a determination of whether blockade of the CD10...; 关键词：IMMUNOTOXIN SAPORIN CD8 T lymphocytes pancreatic islets transplantation THYMUS

Immunotoxins and Cancer Therapy被引量：2: 《Cellular & Molecular Immunology》2005年第2期106-112,共7页ZhengLi TaoYu PingZhao JieMa; In the past decade,an increased amount of clinicallyloriented research involving immunotoxins has been published. Immunotoxins are a group of artificially-made cytotoxic molecules targeting cancer cells.These molecule...; 关键词：IMMUNOTOXIN cancer therapy Pseudomonas exotoxin SCFV

Primary targeting of recombinant Fv-immunotoxin hscFv_(25)-mTNFα against hepatocellular carcinoma被引量：1: 《World Journal of Gastroenterology》2004年第13期1872-1875,共4页JingZhang Yan-FangLiu Shou-JingYang QingQiao HongCheng Chuan-ShanZhang Fu-ChengMa Hua-ZhangGuo; Supported by Military 95 Major Supplementary Project,No.98M098; AIM: To obtain human recombinant Fv-immunotoxin hscFv25-mTNFα (mutant human TNFαfused to human scFv25) against hepatocellular carcinoma (HCC).METHODS: Two relevant sites of enzymatic digestion were added to mTNFα b...; 关键词：重组器官 Fv-抗毒素 hscFv25-mTNFα 肝细胞癌肿瘤 HCC

Purification and characterization of Moschatin, a novel type Ⅰ ribosomeinactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells被引量：8: 《Cell Research》2003年第5期369-374,共6页HENG CHUAN XIA FENG LI ZHEN LI Zu CHUAN ZHANG; A novel ribosome-inactivating protein designated Moschatin from the mature seeds of pumpkin (Cucurbita moschata) has been successively purified to homogeneity, using ammonium sulfate precipitation, CM-cellulose 52 col...; 关键词：ribosome-inactivating protein (RIP) Moschatin immunotoxin.

Preliminary study on immunotoxin for the prevention of Schistosomiasis japonica: 《Chinese Medical Journal》2001年第7期100-100,共1页冯振卿李芸茜仇镇宁李玉华彭韬管晓虹; 关键词：镇宁李玉

Immunotoxin depletion of T cells and its effect on hematopoietic progenitor cells in human cord blood: 《Chinese Medical Journal》2001年第4期19-23,102-103,共7页许蔓春吕善根沈倍奋黎燕; ThisresearchworkwassupportedbyChinaNational 863Program(No 10 2 0 9 0 1 0 3 ); Objective To study the selective toxicity of immunotoxin (IT) on T cells in cord blood and simultaneously determine its effect on hematopoietic progenitor cells Methods The percentage of CD 5 and CD 8 T c...; 关键词：fetal blood · immunotoxin · T cell depletion · hematopoietic stem cells

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