Themis releases the brakes on TCR signaling during thymocyte selection by disabling SHP-1  

作　　者：Laura Patrussi Cosima T Baldari 

机构地区：[1]Department of Life Sciences,University of Siena,Siena 53100,Italy

出　　处：《Cellular & Molecular Immunology》2017年第9期724-726,共3页中国免疫学杂志（英文版）

摘　　要：In this issue of Nature Immunology,Choi and colleagues1 identify a key function of the T cell-specific protein thymocyte-expressed molecule involved in selection(THEMIS)in T cell development.They demonstrate that the two structural CABIT(cysteine-containing all beta in THEMIS)modules contained in this protein are able to directly bind to the phosphotyrosine-phosphatase(PTP)domain of SHP-1(Src homology region 2 domain-containing phosphatase-1)and inhibit its phosphatase activity by increasing the susceptibility of its catalytic site to oxidation.

关 键 词：development. RELEASE SUSCEPTIBILITY 

分 类 号：P35[天文地球—空间物理学]