Immunomodulation with rabbit anti-thymocyte globulin in solid organ transplantation  

作　　者：Giovanbattista Ippoliti Marco Lucioni Giuseppe Leonardi Marco Paulli 

机构地区：[1]Internal Medicine,Policlinico di Monza [2]Division of Cardiac Surgery,University of Pavia School of Medicine,Foundation "IRCCS San Matteo" Hospital [3]Anatomic Pathology,Foundation IRCCS Policlinico San Matteo,University of Pavia [4]Advanced Heart Failure Unit,AO Universitaria "Policlinico--V.Emanuele"

出　　处：《World Journal of Transplantation》2015年第4期261-266,共6页世界移植杂志

摘　　要：Rabbit anti-thymocyte globulin's manifold mechanisms of action may be attribuited to its polyclonal nature. Its T-cell depleting effect on lymphoid cells is well established: Occurring in the blood and secondary lymphoid tissues, depletion proceeds through complement-dependent lysis, opsonization and apoptotic pathways. Clinical studies have shown that rabbit antithymocyte globulin's immunomodulatory effect extends beyond the initial T-cell depletion and up to the period during which lymphocyte populations begin to recover. The drug is able to mediate immunomodulation and graft tolerance by functionally inactivating cell surface receptors involved in antigen recognition, leukocyte trafficking and leukocyte endothelium adhesion. The complex and prolonged immunomodulation induced by this drug contributes to its efficacy in solid organ transplantation, mainly by reducing the incidence of acute graft rejection.Rabbit anti-thymocyte globulin's manifold mechanisms of action may be attribuited to its polyclonal nature. Its T-cell depleting effect on lymphoid cells is well established: Occurring in the blood and secondary lymphoid tissues, depletion proceeds through complement-dependent lysis, opsonization and apoptotic pathways. Clinical studies have shown that rabbit antithymocyte globulin's immunomodulatory effect extends beyond the initial T-cell depletion and up to the period during which lymphocyte populations begin to recover. The drug is able to mediate immunomodulation and graft tolerance by functionally inactivating cell surface receptors involved in antigen recognition, leukocyte trafficking and leukocyte endothelium adhesion. The complex and prolonged immunomodulation induced by this drug contributes to its efficacy in solid organ transplantation, mainly by reducing the incidence of acute graft rejection.

关 键 词：RABBIT anti-thymocyte GLOBULIN Solid ORGAN TRANSPLANTATION Induction therapy IMMUNOMODULATION 

分 类 号：R[医药卫生]