多发性骨髓瘤患者血管细胞间黏附分子VCAM-1的表达及其意义  

Expression of Vascular Cell Adhesion Molecule-1 in Patients with Multiple Myeloma and Its Significance

作　　者：刘增艳[1] 陆化[1] 刘澎[1] 陈丽娟[1] 王丽霞[1] 陆世丰[1] 李建勇[1] 

机构地区：[1]南京医科大学第一附属医院、江苏省人民医院血液科,江苏南京210029

出　　处：《中国实验血液学杂志》2009年第2期382-384,共3页Journal of Experimental Hematology

基　　金：江苏省高校自然科学基础研究资助项目(编号07KJB320074);国家自然科学基金资助项目(编号30500603);江苏省社会发展基金项目(编号BS2006071)

摘　　要：本研究旨在观察多发性骨髓瘤患者血管细胞间黏附分子(VCAM-1)的表达,并分析其意义。采用RT-PCR方法检测23例多发性骨髓瘤患者骨髓单个核细胞VCAM-1mRNA水平的表达。结果显示:初治及复发/难治性多发性骨髓瘤患者黏附分子VCAM-1的表达较正常对照组及平台期患者明显升高,p<0.05,初发组与复发/难治组之间表达无显著差异(p>0.05)。结论:多发性骨髓瘤患者黏附分子表达增加,其在骨髓瘤发病机制中起重要作用。In order to investigate the expression of vascular cell adhesion molecule-1 （ VCAM-1 ） in patients with multiple myeloma and its significance, the expression of VCAM-1 in 23 patients were detected by reverse transcription-PCR（RT-PCR） and then compared with that in normal control. The results showed that the expression of VCAM-1 in patients with newly diagnosed and relapsed/refractory multiple myeloma was much higher than that in normal control and in patients reached plateau stage （p 〈 0.05 ）. There was no statistically significant difference between newly diagnosed and relapsed/refractory patients （p 〉 0.05 ）. It is concluded that the expression of VCAM-1 in patients with multiple myeloma is abnormal, which may be an important factor for the pathogenesis of multiple myeloma.

关 键 词：多发性骨髓瘤 血管细胞间黏附分子 RT-PCR 

分 类 号：R733.7[医药卫生—肿瘤]