New Fungicidally Active Pyrazolyl-Substituted 1,3,4-Thiadiazole Compounds and Their Preparation  

作　　者：Han Song CHEN Zheng Ming LI Yu Feng HAN Zhong Wen WANG(State Key Laboratory of Elemento-Organic Chemistry,Institute of Elemento-Organic Chemistry. Nankai University. Tianjin 300071) 

出　　处：《Chinese Chemical Letters》1999年第5期365-366,共2页中国化学快报（英文版）

摘　　要：The potassium dithiocarbazate 2 was obtained through condensation of 5-pyrazole hydrazide 1 with carbon disulfide in ethanolic potassium hydroxide. and its cyclization gave 5-pyrazolyl-1,3,4-thiadiazole-2-thione 3 in concentrated sulfuric acid. Alkylation of 3 yielded 2-alkylthio-5-pyrazolyl-1,3,4-thiadiazole 4. The preliminary bioassay tests indicated that compounds 3 and 4 have fungicidal activity.The potassium dithiocarbazate 2 was obtained through condensation of 5-pyrazole hydrazide 1 with carbon disulfide in ethanolic potassium hydroxide. and its cyclization gave 5-pyrazolyl-1,3,4-thiadiazole-2-thione 3 in concentrated sulfuric acid. Alkylation of 3 yielded 2-alkylthio-5-pyrazolyl-1,3,4-thiadiazole 4. The preliminary bioassay tests indicated that compounds 3 and 4 have fungicidal activity.

关 键 词：PYRAZOLE 1 3 4-THIADIAZOLE biheterocyclic compound FUNGICIDE 

分 类 号：O626[理学—有机化学]