苯妥英钠对小鼠急性低压缺氧学习记忆障碍的影响  

Effects of diphenylhydantoin on learning and memory impairment induced by hypobaric hypoxia in mice

作　　者：顾饶胜[1] 徐斌[1] 沈楠[1] 张方[1] 王艳春[1] 

机构地区：[1]空军医学高等专科学校,吉林市132013

出　　处：《空军医高专学报》1999年第2期74-77,共4页

摘　　要：将40只体重20～24g昆明种小鼠随机分为4组,在建立急性低压缺氧导致小鼠学习记忆障碍模型基础上,采用跳台和避暗两种实验方法观察了苯妥英钠(DPH)对小鼠学习记忆障碍的影响.结果表明,急性低压缺氧(8km,停留30min)可导致小鼠学习记忆障碍;灌服DPH(40mg/kg)有一定的防治作用.Forty mice were randomly divided into 4 groups and models of learning and memory impairment induced by hypobaric hypoxia were established. The protective effects of di-phenylhydantoin (DPH) on the learning and memory impairment were studied by step-down test and step-through test. The result indicated that hypobaric hypoxia (stop at 8 km for 30 min) could induce learning and memory impairment in mice while DPH (40 mg/kg) could protect the learning and memory function from the injury.

关 键 词：低压缺氧 学习记忆 苯妥英钠 

分 类 号：R363[医药卫生—病理学]